Literature DB >> 17417910

A practical Buchwald-Hartwig amination of 2-bromopyridines with volatile amines.

Jie Jack Li1, Zhi Wang, Lorna H Mitchell.   

Abstract

A practical Buchwald-Hartwig amination of 2-bromopyridines with volatile amines is developed in sealed tubes. The method provides an expedient entry to a variety of secondary and tertiary aminopyridines that are otherwise not readily synthesized.

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Year:  2007        PMID: 17417910     DOI: 10.1021/jo070366v

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  3 in total

1.  Simple, Efficient Protocols for the Pd-Catalyzed Cross-Coupling Reaction of Aryl Chlorides and Dimethylamine.

Authors:  Brian K Lee; Mark R Biscoe; Stephen L Buchwald
Journal:  Tetrahedron Lett       Date:  2009-07-01       Impact factor: 2.415

2.  A mild, catalyst-free synthesis of 2-aminopyridines.

Authors:  Bhaskar Poola; Wonken Choung; Michael H Nantz
Journal:  Tetrahedron       Date:  2008-11-24       Impact factor: 2.457

3.  Palladium-catalyzed amination of aryl chlorides and bromides with ammonium salts.

Authors:  Rebecca A Green; John F Hartwig
Journal:  Org Lett       Date:  2014-08-18       Impact factor: 6.005

  3 in total

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