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Literature DB >> 1741743

Transforming-growth-factor-beta activation elements in the distal promoter regions of the rat alpha 1 type I collagen gene.

J D Ritzenthaler¹, R H Goldstein, A Fine, A Lichtler, D W Rowe, B D Smith.

Abstract

We have located a cis-acting element (alpha 1-TAE) within the promoter sequences of the rat collagen alpha 1(I) gene (COL1A1) 1600 bases upstream of the transcription start site which mediates transcriptional activation by transforming growth factor beta (TGF-beta). The functional significance of this region was established by (1) deletion analysis of the alpha 1(I) promoter cloned upstream of the bacterial chloramphenicol acetyltransferase (CAT) gene and (2) by co-transfection of promoter constructs with double-stranded oligonucleotides. DNA-mobility-shift assays with radiolabelled alpha 1-TAE demonstrated increased nuclear binding activity after TGF-beta stimulation. Oligonucleotides encoding the alpha 1-TAE, additional upstream regions within the alpha 1(I) promoter, as well as consensus nuclear-factor-1 (NF-1) sequences, competed with the alpha 1-TAE sequence. The two collagen type I genes are stimulated by TGF-beta through different regions of their promoters.

Entities: Chemical Gene Species

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Year: 1991 PMID： 1741743 PMCID： PMC1130614 DOI： 10.1042/bj2800157

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

38 in total

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Journal: Cell Date: 1988-02-12 Impact factor: 41.582

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27 in total

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