Literature DB >> 7715255

Glucocorticoid-induced down regulation of transforming growth factor-beta 1 in adult rat lung fibroblasts.

S Shull1, N Meisler, M Absher, S Phan, K Cutroneo.   

Abstract

Transforming growth factor-beta 1 mRNA and transforming growth factor beta activity are decreased with exposure of normal adult rat lung fibroblasts to dexamethasone. Dexamethasone caused a decrease in transforming growth factor-beta 1 mRNA within 2 hours, which was sustained at least over a 24-hour period. The decrease in transforming growth factor-beta 1 mRNA was dose related. Dexamethasone treatment of rat lung fibroblasts also resulted in a decrease of transforming growth factor beta activity as determined by the mink lung cell growth inhibition assay. These data indicate that glucocorticoids may regulate collagen synthesis at least in part through the mediation of transforming growth factor-beta 1 in rat lung fibroblasts.

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Year:  1995        PMID： 7715255     DOI： 10.1007/bf02981467

Source DB:  PubMed          Journal:  Lung        ISSN： 0341-2040            Impact factor:   2.584


  24 in total

1.  Glucocorticoids selectively decrease the synthesis of hydroxylated collagen peptides.

Authors:  R A Newman; K R Cutroneo
Journal:  Mol Pharmacol       Date:  1978-01       Impact factor: 4.436

2.  Glucocorticoids decrease the synthesis of type I procollagen mRNAs.

Authors:  D Cockayne; K M Sterling; S Shull; K P Mintz; S Illeyne; K R Cutroneo
Journal:  Biochemistry       Date:  1986-06-03       Impact factor: 3.162

3.  Glucocorticoid-mediated selective reduction of functioning collagen messenger ribonucleic acid.

Authors:  R J Rokowski; J Sheehy; K R Cutroneo
Journal:  Arch Biochem Biophys       Date:  1981-08       Impact factor: 4.013

4.  A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta.

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Journal:  Cell       Date:  1988-02-12       Impact factor: 41.582

5.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

6.  Glucocorticoids change the ratio of type III to type I procollagen extracellularly.

Authors:  S Shull; K R Cutroneo
Journal:  Coll Relat Res       Date:  1986-07

7.  Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes.

Authors:  O AyanlarBatuman; A P Ferrero; A Diaz; S A Jimenez
Journal:  J Clin Invest       Date:  1991-11       Impact factor: 14.808

8.  Differential regulation of the expression of transforming growth factor-beta s 1 and 2 by retinoic acid, epidermal growth factor, and dexamethasone in NRK-49F and A549 cells.

Authors:  D Danielpour; K Y Kim; T S Winokur; M B Sporn
Journal:  J Cell Physiol       Date:  1991-08       Impact factor: 6.384

9.  Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone.

Authors:  M Centrella; T L McCarthy; E Canalis
Journal:  Mol Cell Biol       Date:  1991-09       Impact factor: 4.272

10.  Bleomycin stimulates pro-alpha 1 (I) collagen promoter through transforming growth factor beta response element by intracellular and extracellular signaling.

Authors:  S L King; A C Lichtler; D W Rowe; R Xie; G L Long; M P Absher; K R Cutroneo
Journal:  J Biol Chem       Date:  1994-05-06       Impact factor: 5.157
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Authors:  P A Beckett; P H Howarth
Journal:  Thorax       Date:  2003-02       Impact factor: 9.139

2.  Circulating transforming growth factor beta 1 (TGF-beta1) in Guillain-Barré syndrome: decreased concentrations in the early course and increase with motor function.

Authors:  A Créange; L Bélec; B Clair; J D Degos; J C Raphaël; R K Gherardi
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-02       Impact factor: 10.154

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Journal:  J Asthma Allergy       Date:  2022-05-11

4.  Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats.

Authors:  W A Dik; R J McAnulty; M A Versnel; B A E Naber; L J I Zimmermann; G J Laurent; S E Mutsaers
Journal:  Thorax       Date:  2003-09       Impact factor: 9.139

5.  Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis.

Authors:  Christoph Anacker; Annamaria Cattaneo; Alessia Luoni; Ksenia Musaelyan; Patricia A Zunszain; Elena Milanesi; Joanna Rybka; Alessandra Berry; Francesca Cirulli; Sandrine Thuret; Jack Price; Marco A Riva; Massimo Gennarelli; Carmine M Pariante
Journal:  Neuropsychopharmacology       Date:  2012-12-06       Impact factor: 7.853

Review 6.  Y It Matters-Sex Differences in Fetal Lung Development.

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Journal:  Biomolecules       Date:  2022-03-11
  6 in total

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