| Literature DB >> 17406488 |
Matthew B Boxer1, Hisashi Yamamoto.
Abstract
The synthesis of the acetaldehyde-derived tris(trimethylsilyl)silyl (super silyl) enol ether is described, as well as its use in the high-yielding aldehyde cross-aldol reaction. The super silyl enol ether shows unprecedented reactivity in giving the 1:1 adduct in very high yield. This reaction is catalyzed by 0.05 mol% of the Brønsted acid triflimide (HNTf2) and is complete within 15 min, making the protocol very attractive for large-scale synthesis.Entities:
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Year: 2006 PMID： 17406488 DOI： 10.1038/nprot.2006.389
Source DB: PubMed Journal: Nat Protoc ISSN： 1750-2799 Impact factor: 13.491