| Literature DB >> 1740334 |
J M Hoovers1, M Mannens, R John, J Bliek, V van Heyningen, D J Porteous, N J Leschot, A Westerveld, P F Little.
Abstract
In this study, we describe the identification and partial characterization of 101 potential human zinc finger protein genes (ZnFPs). These sequences were isolated by hybridization of cosmids, obtained from mouse-human cell lines enriched for chromosome 11p, with an oligonucleotide specific for the "link" sequence between contiguous zinc fingers. Sixty-nine of these cosmids were regionally localized to human prometaphase chromosomes by in situ hybridization. The localization of these cosmids suggests that a number of finger protein genes occur in linked clusters. Their assignment to chromosomes 3p, 11p, 19p, 19qter, 20p, and 21q makes them valuable as markers or "candidate" genes for diseases associated with these chromosome regions.Entities:
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Year: 1992 PMID： 1740334 DOI： 10.1016/0888-7543(92)90372-y
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736