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Literature DB >> 10567577

The zinc finger-associated SCAN box is a conserved oligomerization domain.

Abstract

A number of Cys(2)His(2) zinc finger proteins contain a highly conserved amino-terminal motif termed the SCAN domain. This element is an 80-residue, leucine-rich region that contains three segments strongly predicted to be alpha-helices. In this report, we show that the SCAN motif functions as an oligomerization domain mediating self-association or association with other proteins bearing SCAN domains. These findings suggest that the SCAN domain plays an important role in the assembly and function of this newly defined subclass of transcriptional regulators.

Entities: Chemical Gene Mutation Species

Mesh：

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Year: 1999 PMID： 10567577 PMCID： PMC84969 DOI： 10.1128/MCB.19.12.8526

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

45 in total

1. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis.

Authors: T Noce; Y Fujiwara; M Sezaki; H Fujimoto; T Higashinakagawa
Journal: Dev Biol Date: 1992-10 Impact factor: 3.582

2. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element.

Authors: R M Attar; M Z Gilman
Journal: Mol Cell Biol Date: 1992-05 Impact factor: 4.272

Review 3. Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization.

Authors: P Lamb; S L McKnight
Journal: Trends Biochem Sci Date: 1991-11 Impact factor: 13.807

4. Refolding and association of oligomeric proteins.

Authors: R Jaenicke; R Rudolph
Journal: Methods Enzymol Date: 1986 Impact factor: 1.600

5. Improved prediction of protein secondary structure by use of sequence profiles and neural networks.

Authors: B Rost; C Sander
Journal: Proc Natl Acad Sci U S A Date: 1993-08-15 Impact factor: 11.205

6. A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis.

Authors: P Denny; A Ashworth
Journal: Gene Date: 1991-10-15 Impact factor: 3.688

7. The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription.

Authors: K Chowdhury; M Goulding; C Walther; K Imai; H Fickenscher
Journal: Mech Dev Date: 1992-12 Impact factor: 1.882

8. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity.

Authors: A J Williams; L M Khachigian; T Shows; T Collins
Journal: J Biol Chem Date: 1995-09-22 Impact factor: 5.157

9. High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered.

Authors: J M Hoovers; M Mannens; R John; J Bliek; V van Heyningen; D J Porteous; N J Leschot; A Westerveld; P F Little
Journal: Genomics Date: 1992-02 Impact factor: 5.736

10. Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

Authors: Z Chen; N J Brand; A Chen; S J Chen; J H Tong; Z Y Wang; S Waxman; A Zelent
Journal: EMBO J Date: 1993-03 Impact factor: 11.598

34 in total

The zinc finger-associated SCAN box is a conserved oligomerization domain.

1. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis.

2. Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element.

Review 3. Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization.

4. Refolding and association of oligomeric proteins.

5. Improved prediction of protein secondary structure by use of sequence profiles and neural networks.

6. A zinc finger protein-encoding gene expressed in the post-meiotic phase of spermatogenesis.

7. The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription.

8. Isolation and characterization of a novel zinc-finger protein with transcription repressor activity.

9. High-resolution localization of 69 potential human zinc finger protein genes: a number are clustered.

10. Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

1. The SCAN domain of ZNF174 is a dimer.

Review 2. All in the family: the BTB/POZ, KRAB, and SCAN domains.

3. Gypsy and the birth of the SCAN domain.

4. Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263.

5. The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity.

Review 6. Transposable elements shape the evolution of mammalian development.

7. Crystal optimization and preliminary diffraction data analysis of the SCAN domain of Zfp206.

Review 8. The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution.

9. SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain.

10. ZNF397, a new class of interphase to early prophase-specific, SCAN-zinc-finger, mammalian centromere protein.