Literature DB >> 17399710

Sequence effects of single base loops in intramolecular quadruplex DNA.

Phillip A Rachwal1, Tom Brown, Keith R Fox.   

Abstract

We have examined the properties of intramolecular G-quadruplexes in which the G3 tracts are separated by single base loops. The most stable complex contained 1',2'-dideoxyribose in all three loops, while loops containing T and C were slightly less stable (by about 2 degrees C). Quadruplexes containing loops with single A residues were less stable by 8 degrees C for each T to A substitution. These folded sequences display similar CD spectra, which are consistent with the formation of parallel stranded complexes with double-chain reversal loops. These results demonstrate that loop sequence, and not just length, affects quadruplex stability.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17399710     DOI： 10.1016/j.febslet.2007.03.040

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  47 in total

1.  Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.

Authors:  Sven Lammich; Frits Kamp; Judith Wagner; Brigitte Nuscher; Sonja Zilow; Ann-Katrin Ludwig; Michael Willem; Christian Haass
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

2.  The effect on quadruplex stability of North-nucleoside derivatives in the loops of the thrombin-binding aptamer.

Authors:  Anna Aviñó; Stefania Mazzini; Ruben Ferreira; Raimundo Gargallo; Victor E Marquez; Ramon Eritja
Journal:  Bioorg Med Chem       Date:  2012-06-09       Impact factor: 3.641

3.  Effects of abasic sites on structural, thermodynamic and kinetic properties of quadruplex structures.

Authors:  Veronica Esposito; Luigi Martino; Giuseppe Citarella; Antonella Virgilio; Luciano Mayol; Concetta Giancola; Aldo Galeone
Journal:  Nucleic Acids Res       Date:  2009-12-21       Impact factor: 16.971

4.  Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites.

Authors:  Aurèle Piazza; Michael Adrian; Frédéric Samazan; Brahim Heddi; Florian Hamon; Alexandre Serero; Judith Lopes; Marie-Paule Teulade-Fichou; Anh Tuân Phan; Alain Nicolas
Journal:  EMBO J       Date:  2015-05-08       Impact factor: 11.598

5.  Thermodynamically stable and genetically unstable G-quadruplexes are depleted in genomes across species.

Authors:  Emilia Puig Lombardi; Allyson Holmes; Daniela Verga; Marie-Paule Teulade-Fichou; Alain Nicolas; Arturo Londoño-Vallejo
Journal:  Nucleic Acids Res       Date:  2019-07-09       Impact factor: 16.971

Review 6.  In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?

Authors:  Janos Sagi
Journal:  J Nucleic Acids       Date:  2017-10-18

7.  A toolbox for predicting g-quadruplex formation and stability.

Authors:  Han Min Wong; Oliver Stegle; Simon Rodgers; Julian Leon Huppert
Journal:  J Nucleic Acids       Date:  2010-06-08

8.  A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.

Authors:  Shang-Te Danny Hsu; Peter Varnai; Anthony Bugaut; Anthony P Reszka; Stephen Neidle; Shankar Balasubramanian
Journal:  J Am Chem Soc       Date:  2009-09-23       Impact factor: 15.419

9.  Stability of intramolecular quadruplexes: sequence effects in the central loop.

Authors:  Aurore Guédin; Patrizia Alberti; Jean-Louis Mergny
Journal:  Nucleic Acids Res       Date:  2009-07-06       Impact factor: 16.971

10.  Molecular models for intrastrand DNA G-quadruplexes.

Authors:  Federico Fogolari; Haritha Haridas; Alessandra Corazza; Paolo Viglino; Davide Corà; Michele Caselle; Gennaro Esposito; Luigi E Xodo
Journal:  BMC Struct Biol       Date:  2009-10-07
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.