PURPOSE: To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15 or FS30 femtosecond laser (IntraLase Corp.). SETTING: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. METHODS: Twenty-three patients (31 eyes) who had LASIK with flap creation using the FS15 or FS30 laser were assessed by clinical examination and confocal microscopy in a nonrandomized parallel treatment group comparative trial. Eight FS15 patients (15 eyes) were examined preoperatively and 3 months postoperatively, and 14 FS30 patients (15 eyes) were examined 3 months postoperatively. RESULTS: No patient in either group had clinically significant flap interface haze. One FS15 eye and 1 FS30 eye had significant keratocyte activation at the flap interface. The mean difference between the actual flap thickness and intended flap thickness was 16.8 microm +/- 11.1 (SD) and 13.9 +/- 7.1 microm in the FS15 group and FS30 group, respectively (P = .49). The mean measured interface reflectivity was 156.4 +/- 88.6 confocal backscatter units (CBU) and 104.8 +/- 91.2 CBU, respectively (P = .15). The mean density of interface particles was 21.4 +/- 14.8 particles/mm(2) in the FS15 group and 11.0 +/- 7.1 particles/mm(2) in the FS30 group (P<.05). CONCLUSIONS: Both the FS15 and FS30 lasers provided more reproducible flap thickness and fewer interface particles than previously observed using microkeratomes. The response of corneal keratocytes to intra-LASIK was reduced compared with previous results in which higher raster energies were used. Compared with the FS15, there was an apparent reduction in overall interface reflectivity and fewer interface particles with the FS30 laser.
PURPOSE: To compare the response of the cornea to laser in situ keratomileusis (LASIK) with flap creation using the IntraLase FS15 or FS30 femtosecond laser (IntraLase Corp.). SETTING: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. METHODS: Twenty-three patients (31 eyes) who had LASIK with flap creation using the FS15 or FS30 laser were assessed by clinical examination and confocal microscopy in a nonrandomized parallel treatment group comparative trial. Eight FS15 patients (15 eyes) were examined preoperatively and 3 months postoperatively, and 14 FS30 patients (15 eyes) were examined 3 months postoperatively. RESULTS: No patient in either group had clinically significant flap interface haze. One FS15 eye and 1 FS30 eye had significant keratocyte activation at the flap interface. The mean difference between the actual flap thickness and intended flap thickness was 16.8 microm +/- 11.1 (SD) and 13.9 +/- 7.1 microm in the FS15 group and FS30 group, respectively (P = .49). The mean measured interface reflectivity was 156.4 +/- 88.6 confocal backscatter units (CBU) and 104.8 +/- 91.2 CBU, respectively (P = .15). The mean density of interface particles was 21.4 +/- 14.8 particles/mm(2) in the FS15 group and 11.0 +/- 7.1 particles/mm(2) in the FS30 group (P<.05). CONCLUSIONS: Both the FS15 and FS30 lasers provided more reproducible flap thickness and fewer interface particles than previously observed using microkeratomes. The response of corneal keratocytes to intra-LASIK was reduced compared with previous results in which higher raster energies were used. Compared with the FS15, there was an apparent reduction in overall interface reflectivity and fewer interface particles with the FS30 laser.
Authors: W Matthew Petroll; R Wayne Bowman; H Dwight Cavanagh; Steven M Verity; V Vinod Mootha; James P McCulley Journal: J Refract Surg Date: 2008-10 Impact factor: 3.573
Authors: Dan Z Reinstein; Timothy J Archer; Marine Gobbe; Ronald H Silverman; D Jackson Coleman Journal: J Refract Surg Date: 2009-11-16 Impact factor: 3.573
Authors: Naoyuki Morishige; Anna Kesler-Diaz; Andrew J Wahlert; Ronald M Kurtz; Tibor Juhasz; Melvin Sarayba; James V Jester Journal: Exp Eye Res Date: 2008-03-06 Impact factor: 3.467