Literature DB >> 17397227

Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library.

Dyeison Antonow1, Nectaroula Cooper, Philip W Howard, David E Thurston.   

Abstract

A 66-member C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library has been successfully synthesized in parallel via Suzuki coupling using PS-PPh3Pd (catalyst) and PS-DEAM (scavenger) under microwave radiation. Library members were obtained in sufficient yield (up to 91%) and purity (85-98% crude) for biological evaluation.

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Year:  2007        PMID： 17397227     DOI： 10.1021/cc0601332

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  5 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

Review 2.  Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines.

Authors:  Barbara Gerratana
Journal:  Med Res Rev       Date:  2010-06-13       Impact factor: 12.944

3.  Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters.

Authors:  Maciej Kaliszczak; Dyeison Antonow; Katan I Patel; Philip Howard; Duncan I Jodrell; David E Thurston; Sylvie M Guichard
Journal:  AAPS J       Date:  2010-08-12       Impact factor: 4.009

4.  Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog.

Authors:  Wei Li; ShenChieh Chou; Ankush Khullar; Barbara Gerratana
Journal:  Appl Environ Microbiol       Date:  2009-03-06       Impact factor: 4.792

5.  Biosynthesis of sibiromycin, a potent antitumor antibiotic.

Authors:  Wei Li; Ankush Khullar; Shenchieh Chou; Ashley Sacramo; Barbara Gerratana
Journal:  Appl Environ Microbiol       Date:  2009-03-06       Impact factor: 4.792
  5 in total

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