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Literature DB >> 19270147

Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analog.

Wei Li¹, ShenChieh Chou, Ankush Khullar, Barbara Gerratana.

Abstract

Tomaymycin produced by Streptomyces achromogenes is a naturally produced pyrrolobenzodiazepine (PBD). The biosynthetic gene cluster for tomaymycin was identified and sequenced. The gene cluster analysis reveals a novel biosynthetic pathway for the anthranilate moiety of PBDs. Gene replacement and chemical complementation studies were used to confirm the proposed biosynthetic pathway.

Entities: Chemical Species

Mesh：

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Year: 2009 PMID： 19270147 PMCID： PMC2681672 DOI： 10.1128/AEM.02325-08

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

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