BACKGROUND: Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS: Our hypothesis was that subtle pre-operative impairments of attention will be associated with risk of post-operative delirium. METHOD: A prospective study evaluating pre- and post-operative neuropsychological performance in older (> or =70) consecutive elective admissions for orthopaedic surgery, and free of dementia (n = 100) was initiated in a general medical hospital. RESULTS: Pre-operative attentional deficits were closely associated with delirium. Patients who developed post-surgical delirium had significantly slower mean reaction times (p < or = 0.011) and greater variability of reaction time (p = 0.017). A 4- to 5-fold increased risk of delirium was observed for people one standard deviation above the sample means on these variables. CONCLUSIONS: The present study describes a measurement of attentional performance which could form the basis of a neuropsychological marker of delirium.
BACKGROUND: Previously, key studies of the risk profile for post-surgical delirium have focused on general medical and non-elective patients, few have examined elective cohorts. Accurate prediction is imperative for clinical trials and prevention strategies. AIMS/HYPOTHESIS: Our hypothesis was that subtle pre-operative impairments of attention will be associated with risk of post-operative delirium. METHOD: A prospective study evaluating pre- and post-operative neuropsychological performance in older (> or =70) consecutive elective admissions for orthopaedic surgery, and free of dementia (n = 100) was initiated in a general medical hospital. RESULTS: Pre-operative attentional deficits were closely associated with delirium. Patients who developed post-surgical delirium had significantly slower mean reaction times (p < or = 0.011) and greater variability of reaction time (p = 0.017). A 4- to 5-fold increased risk of delirium was observed for people one standard deviation above the sample means on these variables. CONCLUSIONS: The present study describes a measurement of attentional performance which could form the basis of a neuropsychological marker of delirium.
Authors: Clive Ballard; Emma Jones; Nathan Gauge; Dag Aarsland; Odd Bjarte Nilsen; Brian K Saxby; David Lowery; Anne Corbett; Keith Wesnes; Eirini Katsaiti; James Arden; Derek Amoako; Derek Amaoko; Nicholas Prophet; Balaji Purushothaman; David Green Journal: PLoS One Date: 2012-06-15 Impact factor: 3.240
Authors: Mark L van Zuylen; Jeroen Hermanides; Werner Ten Hoope; Benedikt Preckel; Diederik van de Beek; Willem A van Gool; Niels Schoenmaker Journal: Alzheimers Dement (N Y) Date: 2020-06-16
Authors: Petros Kitsis; Theopisti Zisimou; Ioannis Gkiatas; Ioannis Kostas-Agnantis; Ioannis Gelalis; Anastasios Korompilias; Emilios Pakos Journal: Life (Basel) Date: 2022-02-20