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Literature DB >> 17395087

Physiological, pathological and potential therapeutic roles of ghrelin.

Adelino F Leite-Moreira¹, João-Bruno Soares.

Abstract

Ghrelin, a hormone that is produced mainly by the stomach, was identified originally as the endogenous ligand of the growth hormone secretagogue (GHS) receptor. Ghrelin might also be synthesized in other organs, where it might have autocrine or paracrine effects. GHS receptors are present in tissues other than the hypothalamus and pituitary, which indicates that ghrelin has other effects in addition to stimulating the release of growth hormone. Recently, it has been suggested that ghrelin might be involved in the pathogenesis of many diseases and be a therapeutic target in these diseases. Here, we provide an overview of the physiological effects of ghrelin and of its pathological and potential therapeutic roles.

Entities: Chemical Disease Gene

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Year: 2007 PMID： 17395087 DOI： 10.1016/j.drudis.2007.02.009

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

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Cited

36 in total

10. Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.

Authors: Kirstie A Bennett; Christopher J Langmead; Alan Wise; Graeme Milligan
Journal: Mol Pharmacol Date: 2009-07-22 Impact factor: 4.436

Physiological, pathological and potential therapeutic roles of ghrelin.

Review 1. Clinical application of ghrelin in the field of surgery.

2. Mapping analysis of ghrelin producing cells in the human stomach associated with chronic gastritis and early cancers.

3. Low prevalence of obesity in Behçet's disease is associated with high obestatin level.

4. Distribution of ghrelin-producing cells in the gastrointestinal tract of pigs at different ages.

5. Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy.

6. Assessment of serum and urine ghrelin levels in patients with acute stroke.

7. Chronic caloric restriction induces forestomach hypertrophy with enhanced ghrelin levels during aging.

8. Ghrelin and obestatin levels in rheumatoid arthritis.

9. Ghrelin and cardiovascular diseases.

10. Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.