INTRODUCTION: Almost all patients with breast cancer and bone metastases suffer bone pain. Many receive bisphosphonate therapy only when the pain becomes unbearable or there is a direct threat of skeletal complications. DISCUSSION: However, clinical trial data demonstrate that bisphosphonates offer significant and sustained relief from bone pain and can also improve quality of life in patients with metastatic breast cancer. CONCLUSION: Moreover, new treatment schedules using high dose bisphosphonates can offer rapid relief of acute, severe bone pain.
INTRODUCTION: Almost all patients with breast cancer and bone metastases suffer bone pain. Many receive bisphosphonate therapy only when the pain becomes unbearable or there is a direct threat of skeletal complications. DISCUSSION: However, clinical trial data demonstrate that bisphosphonates offer significant and sustained relief from bone pain and can also improve quality of life in patients with metastatic breast cancer. CONCLUSION: Moreover, new treatment schedules using high dose bisphosphonates can offer rapid relief of acute, severe bone pain.
Authors: A T van Holten-Verzantvoort; A H Zwinderman; N K Aaronson; J Hermans; B van Emmerik; F S van Dam; B van den Bos; O L Bijvoet; F J Cleton Journal: Eur J Cancer Date: 1991 Impact factor: 9.162
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