Literature DB >> 17387274

Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound.

Xin-jiang Wu1, Xianxin Hua.   

Abstract

Oncogenic transformation usually leads to increase of cellular reactive oxygen species (ROS) level that renders the cells vulnerable to additional ROS production. By targeting ROS, a naturally occurring ROS-inducing compound, beta-phenylethyl isothiocyanate (PEITC), selectively kills the transformed cells but not normal cells.

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Year:  2007        PMID： 17387274     DOI： 10.4161/cbt.6.5.4092

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  29 in total

Review 1.  Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.

Authors:  Parul Gupta; Stephen E Wright; Sung-Hoon Kim; Sanjay K Srivastava
Journal:  Biochim Biophys Acta       Date:  2014-08-23

2.  Loss of ERα and FOXA1 expression in a progression model of luminal type breast cancer: insights from PyMT transgenic mouse model.

Authors:  Kasi McCune; Rutika Mehta; Mangesh A Thorat; Sunil Badve; Harikrishna Nakshatri
Journal:  Oncol Rep       Date:  2010-11       Impact factor: 3.906

Review 3.  Hydrogen sulfide in biochemistry and medicine.

Authors:  Benjamin Lee Predmore; David Joseph Lefer; Gabriel Gojon
Journal:  Antioxid Redox Signal       Date:  2012-04-20       Impact factor: 8.401

4.  Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells.

Authors:  Dong Xiao; Anna A Powolny; Michelle B Moura; Eric E Kelley; Ajay Bommareddy; Su-Hyeong Kim; Eun-Ryeong Hahm; Daniel Normolle; Bennett Van Houten; Shivendra V Singh
Journal:  J Biol Chem       Date:  2010-06-22       Impact factor: 5.157

5.  Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy.

Authors:  Subash C Gupta; David Hevia; Sridevi Patchva; Byoungduck Park; Wonil Koh; Bharat B Aggarwal
Journal:  Antioxid Redox Signal       Date:  2012-01-16       Impact factor: 8.401

6.  Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling.

Authors:  Nashi Widodo; Didik Priyandoko; Navjot Shah; Renu Wadhwa; Sunil C Kaul
Journal:  PLoS One       Date:  2010-10-21       Impact factor: 3.240

7.  Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.

Authors:  Dong Xiao; Anna A Powolny; Shivendra V Singh
Journal:  J Biol Chem       Date:  2008-09-03       Impact factor: 5.157

8.  Effect of indole ethyl isothiocyanates on proliferation, apoptosis, and MAPK signaling in neuroblastoma cell lines.

Authors:  Rakesh K Singh; Thilo S Lange; Kyukwang Kim; Yongping Zou; Casey Lieb; Giselle L Sholler; Laurent Brard
Journal:  Bioorg Med Chem Lett       Date:  2007-08-19       Impact factor: 2.823

9.  Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells.

Authors:  Ravi P Sahu; Ruifen Zhang; Sanjay Batra; Yan Shi; Sanjay K Srivastava
Journal:  Carcinogenesis       Date:  2009-06-23       Impact factor: 4.944

Review 10.  Cancer cells with irons in the fire.

Authors:  Laura M Bystrom; Stefano Rivella
Journal:  Free Radic Biol Med       Date:  2014-05-14       Impact factor: 7.376
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