| Literature DB >> 25152445 |
Parul Gupta1, Stephen E Wright2, Sung-Hoon Kim3, Sanjay K Srivastava4.
Abstract
The epidemiological evidence suggests a strong inverse relationship between dietary intake of cruciferous vegetables and the incidence of cancer. Among other constituents of cruciferous vegetables, isothiocyanates (ITC) are the main bioactive chemicals present. Phenethyl isothiocyanate (PEITC) is present as gluconasturtiin in many cruciferous vegetables with remarkable anti-cancer effects. PEITC is known to not only prevent the initiation phase of carcinogenesis process but also to inhibit the progression of tumorigenesis. PEITC targets multiple proteins to suppress various cancer-promoting mechanisms such as cell proliferation, progression and metastasis. Pre-clinical evidence suggests that combination of PEITC with conventional anti-cancer agents is also highly effective in improving overall efficacy. Based on accumulating evidence, PEITC appears to be a promising agent for cancer therapy and is already under clinical trials for leukemia and lung cancer. This is the first review which provides a comprehensive analysis of known targets and mechanisms along with a critical evaluation of PEITC as a future anti-cancer agent.Entities:
Keywords: Chemoprevention; Cruciferous vegetables; Isothiocyanates; PEITC; Reactive oxygen species
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Year: 2014 PMID： 25152445 PMCID： PMC4260992 DOI： 10.1016/j.bbcan.2014.08.003
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002