Literature DB >> 17383765

Hepatitis B virus genetic variability and evolution.

Alan Kay1, Fabien Zoulim.   

Abstract

Hepatitis B virus has been evolving gradually over a long period of time, resulting in a large amount of genetic diversity, despite the constraints imposed by the complex genetic organization of the viral genome. This diversity is partly due to virus/host interactions and partly due to parallel evolution in geographically distinct areas. Recombination also appears to be an important element in HBV evolution. Also, human intervention in the form of mass vaccination and antiviral treatment will reduce the burden of HBV-related liver disease but may also be accelerating evolution of the virus.

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Year:  2007        PMID： 17383765     DOI： 10.1016/j.virusres.2007.02.021

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  100 in total

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