| Literature DB >> 17382873 |
Suvendra N Bhattacharyya1, Witold Filipowicz.
Abstract
The 3'-untranslated region (UTR) of mRNA is crucial for posttranscriptional regulation. In this issue, Vasudevan and Steitz (2007) report a new function for AGO2 and FXR1--two proteins that have been linked to the regulation of microRNAs and translation repression. AGO2 and FXR1 bind to the AU-rich element in the 3'-UTR of TNFalpha mRNA, unexpectedly activating its translation in a cell growth-dependent manner.Entities:
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Year: 2007 PMID： 17382873 DOI： 10.1016/j.cell.2007.02.033
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582