| Literature DB >> 17382568 |
Abstract
The adapter molecules ASC, Ipaf and Cryopyrin/Nalp3 have each been proposed to regulate caspase-1 within a multi-protein complex called the "inflammasome". Activation of caspase-1 leads to the cleavage and activation of pro-inflammatory cytokines such as interleukin (IL)-1beta and IL-18. The analysis of mice deficient in ASC, Ipaf and Cryopyrin/Nalp3 has revealed that the inflammasome is a dynamic entity that is assembled from different adapters in a stimulus-dependent manner.Entities:
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Year: 2007 PMID： 17382568 DOI： 10.1016/j.micinf.2007.01.017
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700