BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage (IPH), known to be associated with plaque instability, may convey a higher stroke risk. The aim of this study was to assess whether the identification of IPH by MRI predicts recurrent clinical cerebrovascular events. METHODS: Sixty-six patients with high-grade symptomatic carotid stenosis underwent MRI of the carotid arteries and were followed until carotid endarterectomy or 30 days. RESULTS: Of the 66 patients with a median follow up of 33.5 days, 44 (66.7%) were found on MRI to have ipsilateral carotid IPH. Fifteen recurrent events were associated with ipsilateral carotid IPH. Only 2 recurrent events occurred in the absence of IPH. IPH increased the risk of recurrent ischemia (hazard ratio=4.8; 95% CI=1.1 to 20.9, P<0.05). CONCLUSIONS: IPH as detected by MRI predicts recurrent cerebrovascular events in patients with symptomatic high-grade carotid stenosis.
BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage (IPH), known to be associated with plaque instability, may convey a higher stroke risk. The aim of this study was to assess whether the identification of IPH by MRI predicts recurrent clinical cerebrovascular events. METHODS: Sixty-six patients with high-grade symptomatic carotid stenosis underwent MRI of the carotid arteries and were followed until carotid endarterectomy or 30 days. RESULTS: Of the 66 patients with a median follow up of 33.5 days, 44 (66.7%) were found on MRI to have ipsilateral carotid IPH. Fifteen recurrent events were associated with ipsilateral carotid IPH. Only 2 recurrent events occurred in the absence of IPH. IPH increased the risk of recurrent ischemia (hazard ratio=4.8; 95% CI=1.1 to 20.9, P<0.05). CONCLUSIONS:IPH as detected by MRI predicts recurrent cerebrovascular events in patients with symptomatic high-grade carotid stenosis.
Authors: Grigorios Korosoglou; Robert G Weiss; Dorota A Kedziorek; Piotr Walczak; Wesley D Gilson; Michael Schär; David E Sosnovik; Dara L Kraitchman; Raymond C Boston; Jeff W M Bulte; Ralph Weissleder; Matthias Stuber Journal: J Am Coll Cardiol Date: 2008-08-05 Impact factor: 24.094
Authors: L Saba; G Micheletti; W Brinjikji; P Garofalo; R Montisci; A Balestrieri; J S Suri; J K DeMarco; G Lanzino; R Sanfilippo Journal: AJNR Am J Neuroradiol Date: 2019-09-26 Impact factor: 3.825
Authors: C Zhu; X Tian; A J Degnan; Z Shi; X Zhang; L Chen; Z Teng; D Saloner; J Lu; Q Liu Journal: AJNR Am J Neuroradiol Date: 2018-05-24 Impact factor: 3.825
Authors: S Narumi; M Sasaki; H Ohba; K Ogasawara; M Kobayashi; T Natori; J Hitomi; H Itagaki; T Takahashi; Y Terayama Journal: AJNR Am J Neuroradiol Date: 2013-10-03 Impact factor: 3.825