Improving excitation and inversion accuracy by optimized RF pulse using genetic algorithm.

In this study, a Genetic Algorithm (GA) is introduced to optimize the multidimensional spatial selective RF pulse to reduce the passband and stopband errors of excitation profile while limiting the transition width. This method is also used to diminish the nonlinearity effect of the Bloch equation for large tip angle excitation pulse design. The RF pulse is first designed by the k-space method and then coded into float strings to form an initial population. GA operators are then applied to this population to perform evolution, which is an optimization process. In this process, an evaluation function defined as the sum of the reciprocal of passband and stopband errors is used to assess the fitness value of each individual, so as to find the best individual in current generation. It is possible to optimize the RF pulse after a number of iterations. Simulation results of the Bloch equation show that in a 90 degrees excitation pulse design, compared with the k-space method, a GA-optimized RF pulse can reduce the passband and stopband error by 12% and 3%, respectively, while maintaining the transition width within 2 cm (about 12% of the whole 32 cm FOV). In a 180 degrees inversion pulse design, the passband error can be reduced by 43%, while the transition is also kept at 2 cm in a whole 32 cm FOV.