| Literature DB >> 17376678 |
Deborah L Moody1, Marcin Dyba, Teresa Kosakowska-Cholody, Nadya I Tarasova, Christopher J Michejda.
Abstract
Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase II and possible anti-tumor agents.Entities:
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Year: 2006 PMID： 17376678 PMCID： PMC2262287 DOI： 10.1016/j.bmcl.2006.09.093
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823