| Literature DB >> 17376453 |
Petr Volf1, Ivana Benkova, Jitka Myskova, Jovana Sadlova, Lenea Campino, Christophe Ravel.
Abstract
Development of Leishmania infantum/Leishmania major hybrids was studied in two sand fly species. In Phlebotomus papatasi, which supported development of L. major but not L. infantum, the hybrids produced heavy late-stage infections with high numbers of metacyclic promastigotes. In the permissive vector Lutzomyia longipalpis, all Leishmania strains included in this study developed well. Hybrids were found to express L. major lipophosphoglycan, apparently enabling them to survive in P. papatasi midgut. The genetic exchange of the hybrids thus appeared to have enhanced their transmission potential and fitness. A potentially serious consequence is the future spread of the hybrids using this peridomestic and antropophilic vector.Entities:
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Year: 2007 PMID： 17376453 PMCID： PMC2839924 DOI： 10.1016/j.ijpara.2007.02.002
Source DB: PubMed Journal: Int J Parasitol ISSN： 0020-7519 Impact factor: 3.981