Literature DB >> 1615326

Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut.

P F Pimenta1, S J Turco, M J McConville, P G Lawyer, P V Perkins, D L Sacks.   

Abstract

Although leishmaniasis is transmitted to humans almost exclusively by the bite of infected phlebotomine sandflies, little is known about the molecules controlling the survival and development of Leishmania parasites in their insect vectors. Adhesion of Leishmania promastigotes to the midgut epithelial cells of the sandfly was found to be an inherent property of noninfective-stage promastigotes, which was lost during their transformation to metacyclic forms, thus permitting the selective release of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release was found to be controlled by specific developmental modifications in terminally exposed saccharides on lipophosphoglycan, the major surface molecule on Leishmania promastigotes.

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Year:  1992        PMID： 1615326     DOI： 10.1126/science.1615326

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  72 in total

1.  Second Jenner international glycoimmunology meeting.

Authors: 
Journal:  Ann Rheum Dis       Date:  1992-11       Impact factor: 19.103

Review 2.  Insight into a conserved lifestyle: protein-carbohydrate adhesion strategies of vector-borne pathogens.

Authors:  Rhoel R Dinglasan; Marcelo Jacobs-Lorena
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

Review 3.  The genetics of Leishmania virulence.

Authors:  Eugenia Bifeld; Joachim Clos
Journal:  Med Microbiol Immunol       Date:  2015-06-06       Impact factor: 3.402

4.  Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi.

Authors:  M E Wilson; R W Vorhies; K A Andersen; B E Britigan
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

5.  Developmental gene expression in Leishmania donovani: differential cloning and analysis of an amastigote-stage-specific gene.

Authors:  H Charest; G Matlashewski
Journal:  Mol Cell Biol       Date:  1994-05       Impact factor: 4.272

6.  Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.

Authors:  Nagila Secundino; Nicola Kimblin; Nathan C Peters; Phillip Lawyer; Althea A Capul; Stephen M Beverley; Salvatore J Turco; David Sacks
Journal:  Cell Microbiol       Date:  2010-01-20       Impact factor: 3.715

7.  Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major.

Authors:  L Proudfoot; P Schneider; M A Ferguson; M J McConville
Journal:  Biochem J       Date:  1995-05-15       Impact factor: 3.857

8.  Structural analysis of novel rhamnose-branched oligosaccharides from the glycophosphosphingolipids of Leptomonas samueli.

Authors:  J O Previato; R Wait; C Jones; L Mendonça-Previato
Journal:  Glycoconj J       Date:  1994-02       Impact factor: 2.916

9.  Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern.

Authors:  Deborah E Dobson; Shaden Kamhawi; Phillip Lawyer; Salvatore J Turco; Stephen M Beverley; David L Sacks
Journal:  PLoS Pathog       Date:  2010-11-11       Impact factor: 6.823

10.  Differential midgut attachment of Leishmania (Viannia) braziliensis in the sand flies Lutzomyia (Nyssomyia) whitmani and Lutzomyia (Nyssomyia) intermedia.

Authors:  Rodrigo P Soares; Carina Margonari; Nágila C Secundino; Maria E Macêdo; Simone M da Costa; Elizabeth F Rangel; Paulo F Pimenta; Salvatore J Turco
Journal:  J Biomed Biotechnol       Date:  2010
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