OBJECTIVE: To assess the association of Medial Temporal lobe Atrophy (MTA) and White Matter Hyperintensities (WMHs) with gray matter perfusion in Mild Cognitive Impairment (MCI). METHODS: 56 MCI patients (age = 69.3 +/- 7.0, 32 females) underwent brain MR scan and (99m)Tc ECD SPECT. We evaluated MTA according to Scheltens' fivepoint scale on T1 MR images, and assessed WMHs using the rating scale for age-related white matter changes on T2-weighted and FLAIR MR images. We divided MCI into age-matched subgroups with high and low MTA and high and low WMHs load. We processed SPECT images with SPM2 following an optimized protocol and performed a voxel-based statistical analysis comparing high vs. low MTA and high vs. low WMHs, setting p-value at 0.001 uncorrected, thresholding cluster extent at 100 voxels, using proportional scaling and entering age and WMHs or MTA respectively as nuisance covariates. RESULTS: MCI with high compared with low MTA showed hypoperfusion in the left hippocampus and in the left parahippocampal gyrus. MCI with high compared with low WMHs showed a hypoperfusion area in the left insular region and superior temporal gyrus. CONCLUSIONS: MTA in MCI is associated with hippocampal gray matter hypoperfusion while WMHs is associated with gray matter hypoperfusion in areas of the insula and temporal neocortex. These results confirm that MTA is associated with local functional changes and suggest that WMHs may be associated with remote brain cortical dysfunction.
OBJECTIVE: To assess the association of Medial Temporal lobe Atrophy (MTA) and White Matter Hyperintensities (WMHs) with gray matter perfusion in Mild Cognitive Impairment (MCI). METHODS: 56 MCI patients (age = 69.3 +/- 7.0, 32 females) underwent brain MR scan and (99m)Tc ECD SPECT. We evaluated MTA according to Scheltens' fivepoint scale on T1 MR images, and assessed WMHs using the rating scale for age-related white matter changes on T2-weighted and FLAIR MR images. We divided MCI into age-matched subgroups with high and low MTA and high and low WMHs load. We processed SPECT images with SPM2 following an optimized protocol and performed a voxel-based statistical analysis comparing high vs. low MTA and high vs. low WMHs, setting p-value at 0.001 uncorrected, thresholding cluster extent at 100 voxels, using proportional scaling and entering age and WMHs or MTA respectively as nuisance covariates. RESULTS: MCI with high compared with low MTA showed hypoperfusion in the left hippocampus and in the left parahippocampal gyrus. MCI with high compared with low WMHs showed a hypoperfusion area in the left insular region and superior temporal gyrus. CONCLUSIONS: MTA in MCI is associated with hippocampal gray matter hypoperfusion while WMHs is associated with gray matter hypoperfusion in areas of the insula and temporal neocortex. These results confirm that MTA is associated with local functional changes and suggest that WMHs may be associated with remote brain cortical dysfunction.
Authors: C R Jack; R C Petersen; Y C Xu; P C O'Brien; G E Smith; R J Ivnik; B F Boeve; S C Waring; E G Tangalos; E Kokmen Journal: Neurology Date: 1999-04-22 Impact factor: 9.910
Authors: Lorena Bresciani; Roberta Rossi; Cristina Testa; Cristina Geroldi; Samantha Galluzzi; Mikko P Laakso; Alberto Beltramello; Hilkka Soininen; Giovanni B Frisoni Journal: Aging Clin Exp Res Date: 2005-02 Impact factor: 3.636
Authors: L O Wahlund; F Barkhof; F Fazekas; L Bronge; M Augustin; M Sjögren; A Wallin; H Ader; D Leys; L Pantoni; F Pasquier; T Erkinjuntti; P Scheltens Journal: Stroke Date: 2001-06 Impact factor: 7.914
Authors: Huichun Xu; Boryana Stamova; Glen Jickling; Yingfang Tian; Xinhua Zhan; Bradley P Ander; Dazhi Liu; Renée Turner; Jonathan Rosand; Larry B Goldstein; Karen L Furie; Piero Verro; S Claiborne Johnston; Frank R Sharp; Charles S Decarli Journal: Stroke Date: 2010-10-21 Impact factor: 7.914
Authors: Emily R Lindemer; David H Salat; Eric E Smith; Khoa Nguyen; Bruce Fischl; Douglas N Greve Journal: Neurobiol Aging Date: 2015-05-28 Impact factor: 4.673
Authors: Alex E Roher; Suzanne L Tyas; Chera L Maarouf; Ian D Daugs; Tyler A Kokjohn; Mark R Emmerling; Zsolt Garami; Marek Belohlavek; Marwan N Sabbagh; Lucia I Sue; Thomas G Beach Journal: Alzheimers Dement Date: 2011-03-09 Impact factor: 21.566
Authors: A Caroli; C Testa; C Geroldi; F Nobili; L R Barnden; U P Guerra; M Bonetti; G B Frisoni Journal: J Neurol Date: 2007-11-09 Impact factor: 4.849
Authors: Flavio Nobili; Giovanni B Frisoni; Florence Portet; Frans Verhey; Guido Rodriguez; Anna Caroli; Jacques Touchon; Piero Calvini; Silvia Morbelli; Fabrizio De Carli; Ugo P Guerra; Laura A Van de Pol; Pieter-Jelle Visser Journal: J Neurol Date: 2008-08-01 Impact factor: 4.849
Authors: Annapaola Prestia; Anna Caroli; Karl Herholz; Eric Reiman; Kewei Chen; William J Jagust; Giovanni B Frisoni Journal: Alzheimers Dement Date: 2013-01-30 Impact factor: 21.566