BACKGROUND AND AIMS: To test the agreement of a visual rating scale of medial temporal lobe atrophy (MTA) with linear and volumetric assessments, and to test its accuracy in discriminating between Alzheimer's disease (AD) patients and controls. METHODS: Participants were 28 patients with AD and 29 healthy controls. MTA was evaluated according to Scheltens' five-point scale. Its accuracy in distinguishing AD patients from controls was evaluated as a stand-alone measure and in association with linear [width of the temporal horn (WTH)] and volumetric [hippocampal volume (HV)] measures. RESULTS: The agreement of this visual rating scale with the other MTA measures was statistically significant (vs WTH and vs HV, p for trend < 0.00005). The visual rating scale showed a good accuracy in distinguishing AD patients from controls [area under the curve (AUC) 0.89, 95% confidence interval (CI) 0.79-0.98]. Although the accuracy of the visual rating scale improved in association with linear WTH (AUC 0.91, 95% CI 0.82-0.99) and in association with HV (AUC 0.93, 95% CI 0.86-1.00), the improvement was not significant. CONCLUSIONS: The visual rating scale of MTA, easily applicable in clinical practice, shows good agreement with more demanding quantitative methods, and can discriminate AD patients from controls with good accuracy.
BACKGROUND AND AIMS: To test the agreement of a visual rating scale of medial temporal lobe atrophy (MTA) with linear and volumetric assessments, and to test its accuracy in discriminating between Alzheimer's disease (AD) patients and controls. METHODS:Participants were 28 patients with AD and 29 healthy controls. MTA was evaluated according to Scheltens' five-point scale. Its accuracy in distinguishing ADpatients from controls was evaluated as a stand-alone measure and in association with linear [width of the temporal horn (WTH)] and volumetric [hippocampal volume (HV)] measures. RESULTS: The agreement of this visual rating scale with the other MTA measures was statistically significant (vs WTH and vs HV, p for trend < 0.00005). The visual rating scale showed a good accuracy in distinguishing ADpatients from controls [area under the curve (AUC) 0.89, 95% confidence interval (CI) 0.79-0.98]. Although the accuracy of the visual rating scale improved in association with linear WTH (AUC 0.91, 95% CI 0.82-0.99) and in association with HV (AUC 0.93, 95% CI 0.86-1.00), the improvement was not significant. CONCLUSIONS: The visual rating scale of MTA, easily applicable in clinical practice, shows good agreement with more demanding quantitative methods, and can discriminate ADpatients from controls with good accuracy.
Authors: Josephine Barnes; L Anne Mitchell; Jonathan Kennedy; Antonio J Bastos-Leite; Suzie Barker; Manja Lehmann; R Chris Nordstrom; Chris Frost; Joseph R Smith; Ellen Garde; Martin N Rossor; Nick C Fox Journal: Neuroradiology Date: 2010-02-27 Impact factor: 2.804
Authors: C Geroldi; R Rossi; C Calvagna; C Testa; L Bresciani; G Binetti; O Zanetti; G B Frisoni Journal: J Neurol Neurosurg Psychiatry Date: 2006-08-04 Impact factor: 10.154
Authors: Juha R Koikkalainen; Hanneke F M Rhodius-Meester; Kristian S Frederiksen; Marie Bruun; Steen G Hasselbalch; Marta Baroni; Patrizia Mecocci; Ritva Vanninen; Anne Remes; Hilkka Soininen; Mark van Gils; Wiesje M van der Flier; Philip Scheltens; Frederik Barkhof; Timo Erkinjuntti; Jyrki M P Lötjönen Journal: Eur Radiol Date: 2019-02-22 Impact factor: 5.315
Authors: Christiane Möller; Wiesje M van der Flier; Adriaan Versteeg; Marije R Benedictus; Mike P Wattjes; Esther L G M Koedam; Philip Scheltens; Frederik Barkhof; Hugo Vrenken Journal: Eur Radiol Date: 2013-10-04 Impact factor: 5.315
Authors: S S Staekenborg; E C W van Straaten; W M van der Flier; R Lane; F Barkhof; P Scheltens Journal: J Neurol Date: 2008-07-18 Impact factor: 4.849
Authors: Giovanni B Frisoni; Wouter J P Henneman; Michael W Weiner; Philip Scheltens; Bruno Vellas; Emma Reynish; Jaroslava Hudecova; Harald Hampel; Katharina Burger; Kaj Blennow; Gunhild Waldemar; Peter Johannsen; Lars-Olof Wahlund; Giancarlo Zito; Paolo M Rossini; Bengt Winblad; Frederik Barkhof Journal: Alzheimers Dement Date: 2008-07 Impact factor: 21.566