| Literature DB >> 17373876 |
Shigehiko Mizutani1, Kiyosumi Shibata, Fumitaka Kikkawa, Akira Hattori, Masafumi Tsujimoto, Masakazu Ishii, Hiroshi Kobayashi.
Abstract
The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.Entities:
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Year: 2007 PMID： 17373876 DOI： 10.1517/14728222.11.4.453
Source DB: PubMed Journal: Expert Opin Ther Targets ISSN： 1472-8222 Impact factor: 6.902