Literature DB >> 17373806

Enantioselective organocatalytic double Michael addition reactions.

Hao Li1, Liansuo Zu, Hexin Xie, Jian Wang, Wei Jiang, Wei Wang.   

Abstract

[reaction: see text] A novel organocatalytic, enantioselective domino double Michael addition reaction of alpha,beta-unsaturated aldehydes with ethyl 4-mercapto-2-butenoate has been developed. The process is promoted by chiral diphenylprolinol TMS ether to give chiral tetrahydrothiophenes in high to excellent levels of enantioselectivities.

Entities:  

Year:  2007        PMID： 17373806     DOI： 10.1021/ol070581y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

Review 1.  Chalcone: A Privileged Structure in Medicinal Chemistry.

Authors:  Chunlin Zhuang; Wen Zhang; Chunquan Sheng; Wannian Zhang; Chengguo Xing; Zhenyuan Miao
Journal:  Chem Rev       Date:  2017-05-10       Impact factor: 60.622

2.  Toward the Synthesis of Nuphar Sesquiterpene Thioalkaloids: Stereodivergent Rhodium-Catalyzed Synthesis of the Thiolane Subunit.

Authors:  Ping Lu; Aaron T Herrmann; Armen Zakarian
Journal:  J Org Chem       Date:  2015-07-28       Impact factor: 4.354

3.  Stereoselective amine-thiourea-catalysed sulfa-Michael/nitroaldol cascade approach to 3,4,5-substituted tetrahydrothiophenes bearing a quaternary stereocenter.

Authors:  Sara Meninno; Chiara Volpe; Giorgio Della Sala; Amedeo Capobianco; Alessandra Lattanzi
Journal:  Beilstein J Org Chem       Date:  2016-04-05       Impact factor: 2.883
  3 in total

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