Literature DB >> 17373763

Chemistry and biology in search of antimetastatic agents.

Lucy Pérez1, Samuel J Danishefsky.   

Abstract

A recent publication is a great example of the inherent potential of exploring the chemical space inspired by natural products. Expanding access to chemical space through organic synthesis allows the discovery of valuable new small-molecule mediators of biological activity.

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Year:  2007        PMID： 17373763     DOI： 10.1021/cb7000395

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  6 in total

1.  Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims.

Authors:  Pavel Nagorny; Isaac Krauss; Jón T Njardarson; Lucy Perez; Christoph Gaul; Guangli Yang; Ouathek Ouerfelli; Samuel J Danishefsky
Journal:  Tetrahedron Lett       Date:  2010-07-28       Impact factor: 2.415

2.  Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.

Authors:  Thordur Oskarsson; Pavel Nagorny; Isaac J Krauss; Lucy Perez; Mihirbaran Mandal; Guangli Yang; Ouathek Ouerfelli; Danhua Xiao; Malcolm A S Moore; Joan Massagué; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2010-03-10       Impact factor: 15.419

3.  Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma.

Authors:  Mikell Paige; George Kosturko; Güllay Bulut; Matthew Miessau; Said Rahim; Jeffrey A Toretsky; Milton L Brown; Aykut Üren
Journal:  Bioorg Med Chem       Date:  2013-11-14       Impact factor: 3.641

4.  3D collagen type I matrix inhibits the antimigratory effect of doxorubicin.

Authors:  Emilie Millerot-Serrurot; Marie Guilbert; Nicolas Fourré; Wojciech Witkowski; Georges Said; Laurence Van Gulick; Christine Terryn; Jean-Marie Zahm; Roselyne Garnotel; Pierre Jeannesson
Journal:  Cancer Cell Int       Date:  2010-08-13       Impact factor: 5.722

5.  Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

Authors:  Jianhua Ju; Scott R Rajski; Si-Kyu Lim; Jeong-Woo Seo; Noël R Peters; F Michael Hoffmann; Ben Shen
Journal:  J Am Chem Soc       Date:  2009-02-04       Impact factor: 15.419

6.  Engineered production of iso-migrastatin in heterologous Streptomyces hosts.

Authors:  Zhiyang Feng; Liyan Wang; Scott R Rajski; Zhinan Xu; Marie F Coeffet-LeGal; Ben Shen
Journal:  Bioorg Med Chem       Date:  2008-11-05       Impact factor: 3.641
  6 in total

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