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Literature DB >> 17372598

What's wrong with drug screening today.

Abstract

Drug screening in the immediate term will be best accomplished by early use of primary cells in which the target of the screen is a network of proteins measured in populations of single cells.

Mesh：

Year: 2007 PMID： 17372598 DOI： 10.1038/nchembio0407-187

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

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Cited

25 in total

1. High-resolution dose-response screening using droplet-based microfluidics.

Authors: Oliver J Miller; Abdeslam El Harrak; Thomas Mangeat; Jean-Christophe Baret; Lucas Frenz; Bachir El Debs; Estelle Mayot; Michael L Samuels; Eamonn K Rooney; Pierre Dieu; Martin Galvan; Darren R Link; Andrew D Griffiths
Journal: Proc Natl Acad Sci U S A Date: 2011-12-27 Impact factor: 11.205

Review 2. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.

Authors: Yan Feng; Timothy J Mitchison; Andreas Bender; Daniel W Young; John A Tallarico
Journal: Nat Rev Drug Discov Date: 2009-07 Impact factor: 84.694

3. High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation.

Authors: Karl-Johan Leuchowius; Malin Jarvius; Malin Wickström; Linda Rickardson; Ulf Landegren; Rolf Larsson; Ola Söderberg; Mårten Fryknäs; Jonas Jarvius
Journal: Mol Cell Proteomics Date: 2009-10-27 Impact factor: 5.911

10. Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions.

Authors: Cuiping Pan; Chanchal Kumar; Sebastian Bohl; Ursula Klingmueller; Matthias Mann
Journal: Mol Cell Proteomics Date: 2008-10-23 Impact factor: 5.911

What's wrong with drug screening today.

1. High-resolution dose-response screening using droplet-based microfluidics.

Review 2. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.

3. High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation.

4. Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis.

Review 5. Induced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous System.

6. High-throughput screening in primary neurons.

7. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators.

Review 8. High-content screening of primary neurons: ready for prime time.

Review 9. Small molecule screening in human induced pluripotent stem cell-derived terminal cell types.

10. Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions.