Literature DB >> 17371245

Phosphoinositide 3-kinase-dependent regulation of phospholipase Cgamma.

T Maffucci1, M Falasca.   

Abstract

Activation of the enzyme PLC (phospholipase C) leads to the formation of second messengers Ins(1,4,5)P(3) and diacylglycerol. RTKs (receptor tyrosine kinases) activate this reaction through PLCgamma isoenzymes. It has been shown that PI3K (phosphoinositide 3-kinase) may regulate PLCgamma activity through the interaction of PI3K product PtdIns(3,4,5)P(3) and the PLCgamma PH domain (pleckstrin homology domain). Here, we analyse the potential functional roles of the PI3K/PLC pathway.

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Year:  2007        PMID： 17371245     DOI： 10.1042/BST0350229

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  12 in total

1.  Phosphatidylinositol-3-kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells.

Authors:  Shekhar Srivastava; Xinjiang Cai; Zhai Li; Yi Sun; Edward Y Skolnik
Journal:  Mol Cell Biol       Date:  2012-05-29       Impact factor: 4.272

2.  Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation.

Authors:  Shuying Yang; Wei Chen; Philip Stashenko; Yi-Ping Li
Journal:  J Cell Sci       Date:  2007-10-01       Impact factor: 5.285

3.  Fibroblast growth factor acts upon the transcription of phospholipase C genes in human umbilical vein endothelial cells.

Authors:  Vincenza Rita Lo Vasco; Martina Leopizzi; Chiara Puggioni; Carlo Della Rocca; Rita Businaro
Journal:  Mol Cell Biochem       Date:  2013-11-16       Impact factor: 3.396

4.  Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.

Authors:  Xinjiang Cai; Shekhar Srivastava; Yi Sun; Zhai Li; Haiyan Wu; Ljiljana Zuvela-Jelaska; Jun Li; Rachel S Salamon; Jonathan M Backer; Edward Y Skolnik
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-29       Impact factor: 11.205

5.  A novel regulatory mechanism links PLCγ1 to PDK1.

Authors:  Claudio Raimondi; Anissa Chikh; Ann P Wheeler; Tania Maffucci; Marco Falasca
Journal:  J Cell Sci       Date:  2012-03-27       Impact factor: 5.285

6.  Dihydroartemisinin inhibits cell proliferation via AKT/GSK3β/cyclinD1 pathway and induces apoptosis in A549 lung cancer cells.

Authors:  Kui Liao; Juan Li; Zhiling Wang
Journal:  Int J Clin Exp Pathol       Date:  2014-12-01

7.  Odorant-stimulated phosphoinositide signaling in mammalian olfactory receptor neurons.

Authors:  K Klasen; E A Corey; F Kuck; C H Wetzel; H Hatt; B W Ache
Journal:  Cell Signal       Date:  2009-09-22       Impact factor: 4.315

Review 8.  Phosphoinositide pathway and the signal transduction network in neural development.

Authors:  Vincenza Rita Lo Vasco
Journal:  Neurosci Bull       Date:  2012-11-14       Impact factor: 5.203

9.  RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation.

Authors:  Shuying Yang; Yi-Ping Li
Journal:  Genes Dev       Date:  2007-07-12       Impact factor: 11.361

10.  A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.

Authors:  Tania Maffucci; Claudio Raimondi; Shadi Abu-Hayyeh; Veronica Dominguez; Gianluca Sala; Ian Zachary; Marco Falasca
Journal:  PLoS One       Date:  2009-12-14       Impact factor: 3.240
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