K J Lee1, K S Jang, Y M Shon. 1. Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Abstract
OBJECTIVES: Experimental data and case reports of intractable epilepsy patients treated with deep brain stimulation (DBS) of the internal nuclei suggest a considerable anticonvulsant effect. We intended to describe the results of DBS on subthalamic nuclei and anterior thalamic nuclei (STN and ATN) from our patients and to evaluate the long-term efficiency and safety of DBS for controlling intractable epilepsy. METHODS: Six patients with refractory epilepsy and inadequate for surgery were implanted with DBS electrodes (3 in STN and 3 in ATN, respectively), switched on after a week of insertion followed by chronological observation. Seizure counts were monitored and compared with pre-implantation baseline. RESULTS: There was significant clinical improvement in respect of reduction of seizure frequency as well as the alleviation of ictal severity in almost patients. The mean reduction in seizure frequency was 62.3% (49.1% from STN vs. 75.4% from ATN). Except one patient (patient 3) with accidental infection on the right anterior chest, no complication or withdrawal of DBS was seen during our study. CONCLUSION: DBS on STN and ATN demonstrated their clear efficiency and relative safety comparable or superior to previous studies during long term follow-up. Subsequent, well designed studies warrant the further increase of the knowledge about antiepileptic effect of DBS.
OBJECTIVES: Experimental data and case reports of intractable epilepsypatients treated with deep brain stimulation (DBS) of the internal nuclei suggest a considerable anticonvulsant effect. We intended to describe the results of DBS on subthalamic nuclei and anterior thalamic nuclei (STN and ATN) from our patients and to evaluate the long-term efficiency and safety of DBS for controlling intractable epilepsy. METHODS: Six patients with refractory epilepsy and inadequate for surgery were implanted with DBS electrodes (3 in STN and 3 in ATN, respectively), switched on after a week of insertion followed by chronological observation. Seizure counts were monitored and compared with pre-implantation baseline. RESULTS: There was significant clinical improvement in respect of reduction of seizure frequency as well as the alleviation of ictal severity in almost patients. The mean reduction in seizure frequency was 62.3% (49.1% from STN vs. 75.4% from ATN). Except one patient (patient 3) with accidental infection on the right anterior chest, no complication or withdrawal of DBS was seen during our study. CONCLUSION: DBS on STN and ATN demonstrated their clear efficiency and relative safety comparable or superior to previous studies during long term follow-up. Subsequent, well designed studies warrant the further increase of the knowledge about antiepileptic effect of DBS.
Authors: Vicenta Salanova; Thomas Witt; Robert Worth; Thomas R Henry; Robert E Gross; Jules M Nazzaro; Douglas Labar; Michael R Sperling; Ashwini Sharan; Evan Sandok; Adrian Handforth; John M Stern; Steve Chung; Jaimie M Henderson; Jacqueline French; Gordon Baltuch; William E Rosenfeld; Paul Garcia; Nicholas M Barbaro; Nathan B Fountain; W Jeffrey Elias; Robert R Goodman; John R Pollard; Alexander I Tröster; Christopher P Irwin; Kristin Lambrecht; Nina Graves; Robert Fisher Journal: Neurology Date: 2015-02-06 Impact factor: 9.910
Authors: Alberto Averna; Valentina Pasquale; Maxwell D Murphy; Maria Piera Rogantin; Gustaf M Van Acker; Randolph J Nudo; Michela Chiappalone; David J Guggenmos Journal: Cereb Cortex Date: 2020-05-14 Impact factor: 5.357