Ahmed Zahran1, Amr El-Husseini, Ahmed Shoker. 1. Royal University Hospital, Department of Medicine, Division of Nephrology, University of Saskatchewan, Saskatoon, Sask., Canada.
Abstract
BACKGROUND: With the increasing knowledge that estimation of glomerular filtration rate (GFR) from serum creatinine (Scr) has limited value, researchers have developed new equations based on serum cystatin C (Cys C). AIM: To compare the performance of serum Cys C and Cys C-based GFR equations to Scr and Scr-based GFR equations. METHODS: A Medline literature search for studies in English. RESULTS: Fourteen studies in kidney transplant patients and 29 in patients with native kidney disease were identified. 70% of studies on transplants favored Cys C over Scr while 60% favored serum Cys C over Scr in patients with native kidney disease. Three studies in transplant patients and 6 in patients with native kidney disease compared the performances of Cys C- and Scr-based equations. 70% of the studies performed on transplantation favored Cys C, while 85% the studies performed in native kidney diseases showed superiority of Cys C-based equations. CONCLUSION: A large number of studies favor Cys C over Scr for the estimation of GFR. Still, many reports show no superiority of Cys C over Scr. Consistent with this, more studies are needed to study the performance of Cys C-based GFR equations. Copyright 2007 S. Karger AG, Basel.
BACKGROUND: With the increasing knowledge that estimation of glomerular filtration rate (GFR) from serum creatinine (Scr) has limited value, researchers have developed new equations based on serum cystatin C (Cys C). AIM: To compare the performance of serum Cys C and Cys C-based GFR equations to Scr and Scr-based GFR equations. METHODS: A Medline literature search for studies in English. RESULTS: Fourteen studies in kidney transplant patients and 29 in patients with native kidney disease were identified. 70% of studies on transplants favored Cys C over Scr while 60% favored serum Cys C over Scr in patients with native kidney disease. Three studies in transplant patients and 6 in patients with native kidney disease compared the performances of Cys C- and Scr-based equations. 70% of the studies performed on transplantation favored Cys C, while 85% the studies performed in native kidney diseases showed superiority of Cys C-based equations. CONCLUSION: A large number of studies favor Cys C over Scr for the estimation of GFR. Still, many reports show no superiority of Cys C over Scr. Consistent with this, more studies are needed to study the performance of Cys C-based GFR equations. Copyright 2007 S. Karger AG, Basel.
Authors: Hu Li; Allison Kuipers; Candace M Kammerer; Clareanne H Bunker; Lewis H Kuller; Iva Miljkovic; Alan L Patrick; Victor W Wheeler; Joseph M Zmuda Journal: Ethn Dis Date: 2013 Impact factor: 1.847