| Literature DB >> 17361034 |
Jay C Strum1, Ron Shehee, David Virley, Jill Richardson, Michael Mattie, Paula Selley, Sujoy Ghosh, Christina Nock, Ann Saunders, Allen Roses.
Abstract
Rosiglitazone was found to simulate mitochondrial biogenesis in mouse brain in an apolipoprotein (Apo) E isozyme-independent manner. Rosiglitazone induced both mitochondrial DNA (mtDNA) and estrogen-stimulated related receptor alpha (ESRRA) mRNA, a key regulator of mitochondrial biogenesis. Transcriptomics and proteomics analysis suggested the mitochondria produced in the presence of human ApoE3 and E4 were not as metabolically efficient as those in the wild type or ApoE knockout mice. Thus, we propose that PPARgamma agonism induces neuronal mitochondrial biogenesis and improves glucose utilization leading to improved cellular function and provides mechanistic support for the improvement in cognition observed in treatment of Alzheimer's patients with rosiglitazone.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17361034 DOI： 10.3233/jad-2007-11108
Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472