OBJECTIVE: The present study examined the relationship between multiple indices of blood pressure (BP) and cognitive function (as measured by the Dementia Rating Scale). BACKGROUND: Cardiovascular disease (CVD) is associated with cognitive dysfunction and cerebrovascular pathology in the elderly and is a known risk factor for stroke and Alzheimer disease. Yet, the mechanisms for the effects of CVD on cognitive function are not well understood. METHODS: Participants were 97 nondemented older adults with CVD who underwent neuropsychologic assessment, and a 2-hour cardiovascular laboratory protocol. RESULTS: After controlling for age and years of education, results of hierarchical linear regression analyses indicate a significant positive relationship between a function of BP variability (SD of systolic BP divided by the average diastolic BP) and cognitive function (R change=0.042, F (1, 85)=5.434, P<0.05). No relationship emerged between any other BP index and cognitive function. CONCLUSIONS: Contrary to expectations, greater BP variability was associated with better, not poorer, cognitive test performance. These findings suggest that the relationship between BP and cognitive function is more complicated than originally conceptualized and requires further investigation.
OBJECTIVE: The present study examined the relationship between multiple indices of blood pressure (BP) and cognitive function (as measured by the Dementia Rating Scale). BACKGROUND:Cardiovascular disease (CVD) is associated with cognitive dysfunction and cerebrovascular pathology in the elderly and is a known risk factor for stroke and Alzheimer disease. Yet, the mechanisms for the effects of CVD on cognitive function are not well understood. METHODS:Participants were 97 nondemented older adults with CVD who underwent neuropsychologic assessment, and a 2-hour cardiovascular laboratory protocol. RESULTS: After controlling for age and years of education, results of hierarchical linear regression analyses indicate a significant positive relationship between a function of BP variability (SD of systolic BP divided by the average diastolic BP) and cognitive function (R change=0.042, F (1, 85)=5.434, P<0.05). No relationship emerged between any other BP index and cognitive function. CONCLUSIONS: Contrary to expectations, greater BP variability was associated with better, not poorer, cognitive test performance. These findings suggest that the relationship between BP and cognitive function is more complicated than originally conceptualized and requires further investigation.
Authors: Siny Tsang; Scott A Sperling; Moon Ho Park; Ira M Helenius; Ishan C Williams; Carol Manning Journal: Cogn Behav Neurol Date: 2017-09 Impact factor: 1.600
Authors: Rianne A A de Heus; Christophe Tzourio; Emily Jo Lynn Lee; Melissa Opozda; Andrew D Vincent; Kaarin J Anstey; Albert Hofman; Kazuomi Kario; Simona Lattanzi; Lenore J Launer; Yuan Ma; Rajiv Mahajan; Simon P Mooijaart; Michiaki Nagai; Ruth Peters; Deborah Turnbull; Yuichiro Yano; Jurgen A H R Claassen; Phillip J Tully Journal: Hypertension Date: 2021-09-20 Impact factor: 9.897
Authors: Kelly M Stanek; John Gunstad; Robert H Paul; Athena Poppas; Angela L Jefferson; Lawrence H Sweet; Karin F Hoth; Andreana P Haley; Daniel E Forman; Ronald A Cohen Journal: J Cardiovasc Nurs Date: 2009 May-Jun Impact factor: 2.083