Ruben Boogaard1, Anthon R Hulsmann2, Leoniek van Veen3, Anja A P H Vaessen-Verberne2, Yen Ni Yap4, Arwen J Sprij5, Govert Brinkhorst6, Barbara Sibbles7, Tom Hendriks8, Sander W W Feith9, Carsten R Lincke10, Annelies E Brandsma10, Paul L P Brand11, Wim C J Hop12, Matthijs de Hoog7, Peter J F M Merkus13. 1. Department of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherland. Electronic address: r.boogaard@erasmusmc.nl. 2. Department of Pediatrics, Amphia Hospital, Breda, Netherland. 3. Reinier de Graaf Gasthuis, Delft, Netherland. 4. Albert Schweitzer Hospital, Dordrecht, Netherland. 5. HagaTeaching Hospital/Juliana Children's Hospital, the Hague, Netherland. 6. Medisch Centrum Alkmaar, Alkmaar, Netherland. 7. Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherland. 8. Catharina Hospital, Eindhoven, Netherland. 9. Sint Franciscus Gasthuis, Rotterdam, Netherland. 10. Medisch Centrum Rijnmond Zuid, Rotterdam, Netherland. 11. Isala Klinieken, Zwolle, Netherland. 12. Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, the Netherlands, Netherland. 13. Department of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherland.
Abstract
BACKGROUND: Treatment of hospitalized infants with respiratory syncytial virus (RSV) bronchiolitis is mainly supportive. Bronchodilators and systemic steroids are often used but do not reduce the length of hospital stay. Because hypoxia and airways obstruction develop secondary to viscous mucus in infants with RSV bronchiolitis, and because free DNA is present in RSV mucus, we tested the efficacy of the mucolytic drug recombinant human deoxyribonuclease (rhDNase). METHODS: In a multicenter, randomized, double-blind, controlled clinical trial, 225 oxygen-dependent infants admitted to the hospital for RSV bronchiolitis were randomly assigned to receive 2.5 mg bid of nebulized rhDNase or placebo until discharge. The primary end point was length of hospital stay. Secondary end points were duration of supplemental oxygen, improvement in symptom score, and number of intensive care admissions. RESULTS: There were no significant differences between the groups with regard to the length of hospital stay (p = 0.19) or the duration of supplemental oxygen (p = 0.07). The ratio (rhDNase/placebo) of geometric means of length of stay was 1.12 (95% confidence interval, 0.96 to 1.33); for the duration of supplemental oxygen, the ratio was 1.28 (95% confidence interval, 0.97 to 1.68). There were no significant differences in the rate of improvement of the symptom score or in the number of intensive care admissions. CONCLUSIONS: Administration of rhDNase did not reduce the length of hospital stay or the duration of supplemental oxygen in oxygen-dependent infants with RSV bronchiolitis.
RCT Entities:
BACKGROUND: Treatment of hospitalized infants with respiratory syncytial virus (RSV) bronchiolitis is mainly supportive. Bronchodilators and systemic steroids are often used but do not reduce the length of hospital stay. Because hypoxia and airways obstruction develop secondary to viscous mucus in infants with RSV bronchiolitis, and because free DNA is present in RSV mucus, we tested the efficacy of the mucolytic drug recombinant human deoxyribonuclease (rhDNase). METHODS: In a multicenter, randomized, double-blind, controlled clinical trial, 225 oxygen-dependent infants admitted to the hospital for RSV bronchiolitis were randomly assigned to receive 2.5 mg bid of nebulized rhDNase or placebo until discharge. The primary end point was length of hospital stay. Secondary end points were duration of supplemental oxygen, improvement in symptom score, and number of intensive care admissions. RESULTS: There were no significant differences between the groups with regard to the length of hospital stay (p = 0.19) or the duration of supplemental oxygen (p = 0.07). The ratio (rhDNase/placebo) of geometric means of length of stay was 1.12 (95% confidence interval, 0.96 to 1.33); for the duration of supplemental oxygen, the ratio was 1.28 (95% confidence interval, 0.97 to 1.68). There were no significant differences in the rate of improvement of the symptom score or in the number of intensive care admissions. CONCLUSIONS: Administration of rhDNase did not reduce the length of hospital stay or the duration of supplemental oxygen in oxygen-dependent infants with RSV bronchiolitis.
Authors: Gilles Cambonie; Christophe Milési; Samir Jaber; Francis Amsallem; Eric Barbotte; Jean-Charles Picaud; Stefan Matecki Journal: Intensive Care Med Date: 2008-07-08 Impact factor: 17.440
Authors: Adel S Alharbi; Mansour Alqwaiee; Mohammed Y Al-Hindi; Rafat Mosalli; Abdullah Al-Shamrani; Saleh Alharbi; Abdullah Yousef; Amal Al Aidaroos; Turki Alahmadi; Aisha Alshammary; Abeer Miqdad; Yazan Said; Abdulrahman Alnemri Journal: Ann Thorac Med Date: 2018 Jul-Sep Impact factor: 2.219
Authors: A Nicolai; M Ferrara; C Schiavariello; F Gentile; M E Grande; C Alessandroni; F Midulla Journal: Early Hum Dev Date: 2013-08-21 Impact factor: 2.079