Literature DB >> 1735185

Thymus lymphocytes in uraemic rats and the effect of thymosin fraction 5 in vivo.

S Ikemoto1, M Kamizuru, N Hayahara, S Okamoto, S Wada, T Kishimoto, M Maekawa.   

Abstract

Thymus lymphocyte subsets in uraemic rats were studied using monoclonal antibodies. Severe and moderate uraemia was induced in rats, and sham-operated and normal rats were used as the controls. As a result, the weight of the thymus decreased in uraemic rats. As for lymphocyte subsets, the frequency of W3/25+OX8+ decreased and those of W3/25-OX8-, W3/25+OX8- and W3/25- OX8+ relatively increased in uraemic rats. All these changes were more significant in severely uraemic than in moderately uraemic rats. When thymosin fraction 5 (TF5) was administered to severely uraemic rats, the weight of the thymus increased and the lymphocytes subsets normalized. These results suggest that uraemia may cause a maturational impairment of thymus lymphocytes by the depression of thymic hormone secretion.

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Year:  1992        PMID： 1735185      PMCID： PMC1554255          DOI： 10.1111/j.1365-2249.1992.tb02978.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  22 in total

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Journal:  Transplantation       Date:  1975-08       Impact factor: 4.939

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Authors:  M M Zatz; A L Goldstein
Journal:  J Immunol       Date:  1985-02       Impact factor: 5.422

4.  Purification and biological activity of thymosin, a hormone of the thymus gland.

Authors:  A L Goldstein; A Guha; M M Zatz; M A Hardy; A White
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

Review 5.  Renal failure and infection.

Authors:  J Z Montgomerie; G M Kalmanson; L B Guze
Journal:  Medicine (Baltimore)       Date:  1968-01       Impact factor: 1.889

6.  Effects of thymosin in vitro in cancer patients and correlation with clinical course after thymosin immunotherapy.

Authors:  P B Chretien; S D Lipson; R W Makuch; D E Kenady; M H Cohen
Journal:  Ann N Y Acad Sci       Date:  1979       Impact factor: 5.691

7.  Immune response in experimentally induced uremia. I. Suppression of mitogen responses by adherent cells in chronic uremia.

Authors:  Y G Alevy; R G Slavin; P Hutcheson
Journal:  Clin Immunol Immunopathol       Date:  1981-04

8.  Increased incidence of malignancy during chronic renal failure.

Authors:  A J Matas; R L Simmons; C M Kjellstrand; T J Buselmeier; J S Najarian
Journal:  Lancet       Date:  1975-04-19       Impact factor: 79.321

9.  Experimental uremia. Description of a model producing varying degrees of stable uremia.

Authors:  D Ormrod; T Miller
Journal:  Nephron       Date:  1980       Impact factor: 2.847

10.  Cellular immunity and lymphocyte populations in developing uremia in the rat.

Authors:  J Raskova; D K Czerwinski; S M Shea; K Raska
Journal:  J Exp Pathol       Date:  1986
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  1 in total

1.  Changes in lymphocyte function and subsets in dogs with naturally occurring chronic renal failure.

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Journal:  Can J Vet Res       Date:  2010-04       Impact factor: 1.310
  1 in total

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