| Literature DB >> 17351631 |
Nara Lee1, Junyu Zhang, Robert J Klose, Hediye Erdjument-Bromage, Paul Tempst, Richard S Jones, Yi Zhang.
Abstract
Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.Entities:
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Year: 2007 PMID： 17351631 DOI： 10.1038/nsmb1216
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369