Literature DB >> 17351262

Preclinical cardiovascular risk assessment in modern drug development.

Brian D Guth1.   

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Year:  2007        PMID: 17351262     DOI: 10.1093/toxsci/kfm026

Source DB:  PubMed          Journal:  Toxicol Sci        ISSN: 1096-0929            Impact factor:   4.849


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  21 in total

1.  Subacute Cardiovascular Toxicity of the Marine Phycotoxin Azaspiracid-1 in Rats.

Authors:  Sara F Ferreiro; Natalia Vilariño; Cristina Carrera; M Carmen Louzao; Antonio G Cantalapiedra; Germán Santamarina; J Manuel Cifuentes; Andrés C Vieira; Luis M Botana
Journal:  Toxicol Sci       Date:  2016-02-10       Impact factor: 4.849

Review 2.  Monitoring haemodynamic changes in rodent models to better inform safety pharmacology: Novel insights from in vivo studies and waveform analysis.

Authors:  Marieke Van Daele; Samantha L Cooper; Patrizia Pannucci; Edward S Wragg; Julie March; Iwan de Jong; Jeanette Woolard
Journal:  JRSM Cardiovasc Dis       Date:  2022-05-23

3.  Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling.

Authors:  N Snelder; B A Ploeger; O Luttringer; D F Rigel; F Fu; M Beil; D R Stanski; M Danhof
Journal:  Br J Pharmacol       Date:  2014-09-05       Impact factor: 8.739

Review 4.  Induced pluripotent stem cells in cardiovascular drug discovery.

Authors:  Mark Mercola; Alexandre Colas; Erik Willems
Journal:  Circ Res       Date:  2013-02-01       Impact factor: 17.367

5.  High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.

Authors:  Fabio Cerignoli; David Charlot; Ross Whittaker; Randy Ingermanson; Piyush Gehalot; Alex Savchenko; David J Gallacher; Rob Towart; Jeffrey H Price; Patrick M McDonough; Mark Mercola
Journal:  J Pharmacol Toxicol Methods       Date:  2012-08-25       Impact factor: 1.950

6.  In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats.

Authors:  Sara F Ferreiro; Natalia Vilariño; Cristina Carrera; M Carmen Louzao; Germán Santamarina; Antonio G Cantalapiedra; Laura P Rodríguez; J Manuel Cifuentes; Andrés C Vieira; K C Nicolaou; Michael O Frederick; Luis M Botana
Journal:  Arch Toxicol       Date:  2013-08-11       Impact factor: 5.153

7.  In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2.

Authors:  Sara F Ferreiro; Natalia Vilariño; M Carmen Louzao; K C Nicolaou; Michael O Frederick; Luis M Botana
Journal:  Toxicon       Date:  2014-10-05       Impact factor: 3.033

8.  Detection of QTc interval prolongation using jacket telemetry in conscious non-human primates: comparison with implanted telemetry.

Authors:  K Derakhchan; R W Chui; D Stevens; W Gu; H M Vargas
Journal:  Br J Pharmacol       Date:  2014-01       Impact factor: 8.739

9.  Successful drug development despite adverse preclinical findings part 1: processes to address issues and most important findings.

Authors:  Robert A Ettlin; Junji Kuroda; Stephanie Plassmann; David E Prentice
Journal:  J Toxicol Pathol       Date:  2010-12-16       Impact factor: 1.628

10.  Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish heart.

Authors:  Satish Srinivas Kitambi; Erik S Nilsson; Petra Sekyrova; Cristian Ibarra; Gilbert Nyah Tekeoh; Michael Andäng; Patrik Ernfors; Per Uhlén
Journal:  BMC Physiol       Date:  2012-03-26
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