Literature DB >> 23371902

Induced pluripotent stem cells in cardiovascular drug discovery.

Mark Mercola1, Alexandre Colas, Erik Willems.   

Abstract

The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development.

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Year:  2013        PMID： 23371902      PMCID： PMC3706265          DOI： 10.1161/CIRCRESAHA.111.250266

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


  114 in total

1.  Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease.

Authors:  Richard P Davis; Simona Casini; Cathelijne W van den Berg; Maaike Hoekstra; Carol Ann Remme; Cheryl Dambrot; Daniela Salvatori; Dorien Ward-van Oostwaard; Arthur A M Wilde; Connie R Bezzina; Arie O Verkerk; Christian Freund; Christine L Mummery
Journal:  Circulation       Date:  2012-05-30       Impact factor: 29.690

2.  A cardiac microRNA governs systemic energy homeostasis by regulation of MED13.

Authors:  Chad E Grueter; Eva van Rooij; Brett A Johnson; Susan M DeLeon; Lillian B Sutherland; Xiaoxia Qi; Laurent Gautron; Joel K Elmquist; Rhonda Bassel-Duby; Eric N Olson
Journal:  Cell       Date:  2012-04-27       Impact factor: 41.582

3.  Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.

Authors:  Ning Sun; Masayuki Yazawa; Jianwei Liu; Leng Han; Veronica Sanchez-Freire; Oscar J Abilez; Enrique G Navarrete; Shijun Hu; Li Wang; Andrew Lee; Aleksandra Pavlovic; Shin Lin; Rui Chen; Roger J Hajjar; Michael P Snyder; Ricardo E Dolmetsch; Manish J Butte; Euan A Ashley; Michael T Longaker; Robert C Robbins; Joseph C Wu
Journal:  Sci Transl Med       Date:  2012-04-18       Impact factor: 17.956

4.  Functional screening identifies miRNAs inducing cardiac regeneration.

Authors:  Ana Eulalio; Miguel Mano; Matteo Dal Ferro; Lorena Zentilin; Gianfranco Sinagra; Serena Zacchigna; Mauro Giacca
Journal:  Nature       Date:  2012-12-05       Impact factor: 49.962

5.  Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis.

Authors:  Alexandre R Colas; Wesley L McKeithan; Thomas J Cunningham; Paul J Bushway; Lana X Garmire; Gregg Duester; Shankar Subramaniam; Mark Mercola
Journal:  Genes Dev       Date:  2012-11-14       Impact factor: 11.361

6.  Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells.

Authors:  Ilanit Itzhaki; Leonid Maizels; Irit Huber; Amira Gepstein; Gil Arbel; Oren Caspi; Liron Miller; Bernard Belhassen; Eyal Nof; Michael Glikson; Lior Gepstein
Journal:  J Am Coll Cardiol       Date:  2012-06-27       Impact factor: 24.094

7.  High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.

Authors:  Fabio Cerignoli; David Charlot; Ross Whittaker; Randy Ingermanson; Piyush Gehalot; Alex Savchenko; David J Gallacher; Rob Towart; Jeffrey H Price; Patrick M McDonough; Mark Mercola
Journal:  J Pharmacol Toxicol Methods       Date:  2012-08-25       Impact factor: 1.950

8.  Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

Authors:  Erik Willems; Joaquim Cabral-Teixeira; Dennis Schade; Wenqing Cai; Patrick Reeves; Paul J Bushway; Marion Lanier; Christopher Walsh; Tomas Kirchhausen; Juan Carlos Izpisua Belmonte; John Cashman; Mark Mercola
Journal:  Cell Stem Cell       Date:  2012-08-03       Impact factor: 24.633

9.  Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers.

Authors:  Peter Lee; Matt Klos; Christian Bollensdorff; Luqia Hou; Paul Ewart; Timothy J Kamp; Jianhua Zhang; Alexandra Bizy; Guadalupe Guerrero-Serna; Peter Kohl; José Jalife; Todd J Herron
Journal:  Circ Res       Date:  2012-05-08       Impact factor: 17.367

10.  Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.

Authors:  Kirsi Kujala; Jere Paavola; Anna Lahti; Kim Larsson; Mari Pekkanen-Mattila; Matti Viitasalo; Annukka M Lahtinen; Lauri Toivonen; Kimmo Kontula; Heikki Swan; Mika Laine; Olli Silvennoinen; Katriina Aalto-Setälä
Journal:  PLoS One       Date:  2012-09-04       Impact factor: 3.240
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  54 in total

Review 1.  Reverse engineering human neurodegenerative disease using pluripotent stem cell technology.

Authors:  Ying Liu; Wenbin Deng
Journal:  Brain Res       Date:  2015-09-28       Impact factor: 3.252

Review 2.  Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes.

Authors:  Karim Sallam; Yingxin Li; Philip T Sager; Steven R Houser; Joseph C Wu
Journal:  Circ Res       Date:  2015-06-05       Impact factor: 17.367

3.  Differentiation of cardiomyocytes and generation of human engineered heart tissue.

Authors:  Kaja Breckwoldt; David Letuffe-Brenière; Ingra Mannhardt; Thomas Schulze; Bärbel Ulmer; Tessa Werner; Anika Benzin; Birgit Klampe; Marina C Reinsch; Sandra Laufer; Aya Shibamiya; Maksymilian Prondzynski; Giulia Mearini; Dennis Schade; Sigrid Fuchs; Christiane Neuber; Elisabeth Krämer; Umber Saleem; Mirja L Schulze; Marita L Rodriguez; Thomas Eschenhagen; Arne Hansen
Journal:  Nat Protoc       Date:  2017-05-11       Impact factor: 13.491

4.  Pluripotent stem cells as a platform for cardiac arrhythmia drug screening.

Authors:  Jordan S Leyton-Mange; David J Milan
Journal:  Curr Treat Options Cardiovasc Med       Date:  2014-09

Review 5.  Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative Diseases.

Authors:  Lei Cao; Lan Tan; Teng Jiang; Xi-Chen Zhu; Jin-Tai Yu
Journal:  Mol Neurobiol       Date:  2014-08-23       Impact factor: 5.590

Review 6.  High throughput physiological screening of iPSC-derived cardiomyocytes for drug development.

Authors:  Juan C Del Álamo; Derek Lemons; Ricardo Serrano; Alex Savchenko; Fabio Cerignoli; Rolf Bodmer; Mark Mercola
Journal:  Biochim Biophys Acta       Date:  2016-03-04

7.  Measuring the contractile forces of human induced pluripotent stem cell-derived cardiomyocytes with arrays of microposts.

Authors:  Marita L Rodriguez; Brandon T Graham; Lil M Pabon; Sangyoon J Han; Charles E Murry; Nathan J Sniadecki
Journal:  J Biomech Eng       Date:  2014-05       Impact factor: 2.097

Review 8.  Recreating the Cardiac Microenvironment in Pluripotent Stem Cell Models of Human Physiology and Disease.

Authors:  Ayhan Atmanli; Ibrahim John Domian
Journal:  Trends Cell Biol       Date:  2016-12-19       Impact factor: 20.808

9.  Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity.

Authors:  Oksana Sirenko; Evan F Cromwell; Carole Crittenden; Jessica A Wignall; Fred A Wright; Ivan Rusyn
Journal:  Toxicol Appl Pharmacol       Date:  2013-10-01       Impact factor: 4.219

10.  Real-Time Force and Frequency Analysis of Engineered Human Heart Tissue Derived from Induced Pluripotent Stem Cells Using Magnetic Sensing.

Authors:  Kevin S Bielawski; Andrea Leonard; Shiv Bhandari; Chuck E Murry; Nathan J Sniadecki
Journal:  Tissue Eng Part C Methods       Date:  2016-09-28       Impact factor: 3.056
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