| Literature DB >> 17350178 |
Igor A C Menezes1, Maxsuel S Marques, Thiago C Santos, Kellyane S Dias, Aline B L Silva, Iderjane C M Mello, Ana C C D Lisboa, Péricles B Alves, Sócrates C H Cavalcanti, Rosilene M Marçal, Angelo R Antoniolli.
Abstract
The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, alpha-pinene, and beta-caryophyllene were the major compounds detected in the essential oil.Entities:
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Year: 2007 PMID： 17350178 DOI： 10.1016/j.fitote.2006.11.020
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882