Literature DB >> 17347184

Reversal of rocuronium-induced (1.2 mg kg-1) profound neuromuscular block by accidental high dose of sugammadex (40 mg kg-1).

A L Molina1, H D de Boer, M Klimek, M Heeringa, J Klein.   

Abstract

Sugammadex is the first selective relaxant binding agent and reverses rocuronium-induced neuromuscular block. A case is reported in which a patient accidentally received a high dose of sugammadex (40 mg kg-1) to reverse a rocuronium-induced (1.2 mg kg-1) profound neuromuscular block. A fast and efficient recovery from profound neuromuscular block was achieved and no adverse events or other safety concerns were reported.

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Year:  2007        PMID: 17347184     DOI: 10.1093/bja/aem057

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN: 0007-0912            Impact factor:   9.166


  7 in total

Review 1.  [Sugammadex. New pharmacological concept for antagonizing rocuronium and vecuronium].

Authors:  H J Sparr; L H Booij; T Fuchs-Buder
Journal:  Anaesthesist       Date:  2009-01       Impact factor: 1.041

2.  Safety, tolerability and pharmacokinetics of sugammadex using single high doses (up to 96 mg/kg) in healthy adult subjects: a randomized, double-blind, crossover, placebo-controlled, single-centre study.

Authors:  Pierre A M Peeters; Michiel W van den Heuvel; Emiel van Heumen; Paul C C M Passier; Jean M W Smeets; Thijs van Iersel; Alex Zwiers
Journal:  Clin Drug Investig       Date:  2010       Impact factor: 2.859

Review 3.  Sugammadex: a review of its use in anaesthetic practice.

Authors:  Lily P H Yang; Susan J Keam
Journal:  Drugs       Date:  2009       Impact factor: 9.546

4.  Changes in intraocular pressure following administration of suxamethonium and endotracheal intubation: Influence of dexmedetomidine premedication.

Authors:  Chandan Kumar Pal; Manjushree Ray; Anjana Sen; Bimal Hajra; Dipankar Mukherjee; Anil Kumar Ghanta
Journal:  Indian J Anaesth       Date:  2011-11

5.  To Evaluate the Efficacy of Intravenous Infusion of Dexmedetomidine as Premedication in Attenuating the Rise of Intraocular Pressure Caused by Succinylcholine in Patients Undergoing Rapid Sequence Induction for General Anesthesia: A Randomized Study.

Authors:  Raj Bahadur Singh; Sanjay Choubey; Saurabh Mishra
Journal:  Anesth Essays Res       Date:  2017 Oct-Dec

6.  Monitoring of Sugammadex Dosing at a Large Tertiary Care Pediatric Hospital.

Authors:  Faizaan Syed; Mehdi Trifa; Joshua C Uffman; Dmitry Tumin; Joseph D Tobias
Journal:  Pediatr Qual Saf       Date:  2018-10-09

7.  Discovery, development, and clinical application of sugammadex sodium, a selective relaxant binding agent.

Authors:  Mark Welliver; John McDonough; Nicholas Kalynych; Robert Redfern
Journal:  Drug Des Devel Ther       Date:  2009-02-06       Impact factor: 4.162

  7 in total

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