OBJECTIVE: To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI). METHODS: Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum. RESULTS: FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls. CONCLUSION: Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.
OBJECTIVE: To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI). METHODS: Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum. RESULTS: FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls. CONCLUSION: Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.
Authors: Joshua S Shimony; Yvette I Sheline; Gina D'Angelo; Adrian A Epstein; Tammie L S Benzinger; Mark A Mintun; Robert C McKinstry; Abraham Z Snyder Journal: Biol Psychiatry Date: 2009-04-17 Impact factor: 13.382
Authors: Amelia Versace; Jorge R C Almeida; Karina Quevedo; Wesley K Thompson; Robert A Terwilliger; Stefanie Hassel; David J Kupfer; Mary L Phillips Journal: Biol Psychiatry Date: 2010-07-02 Impact factor: 13.382
Authors: Mayuresh S Korgaonkar; Stuart M Grieve; Stephen H Koslow; John D E Gabrieli; Evian Gordon; Leanne M Williams Journal: Hum Brain Mapp Date: 2010-12-17 Impact factor: 5.038
Authors: P Cédric M P Koolschijn; Neeltje E M van Haren; Gerty J L M Lensvelt-Mulders; Hilleke E Hulshoff Pol; René S Kahn Journal: Hum Brain Mapp Date: 2009-11 Impact factor: 5.038
Authors: Amelia Versace; Jorge R C Almeida; Stefanie Hassel; Nicholas D Walsh; Massimiliano Novelli; Crystal R Klein; David J Kupfer; Mary L Phillips Journal: Arch Gen Psychiatry Date: 2008-09