| Literature DB >> 17346172 |
Victoria Benson1, Aisling Clare McMahon, Harry Claude Lowe.
Abstract
Current treatments for AMI centre on prompt restoration of epicardial coronary blood flow. Despite improvements, AMI is still associated with significant morbidity and mortality. Novel approaches are therefore keenly sought. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a member of the immunoglobulin superfamily. It is implicated in neutrophil and monocyte-endothelial cell adhesion, processes contributing to myocardial neutrophil infiltration and microvascular coronary slow flow, both viewed as important to the pathophysiologic responses in AMI. ICAM-1 would therefore appear an important potential therapeutic target in this context, and is the subject of this review.Entities:
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Year: 2007 PMID： 17346172 DOI： 10.2174/156652407780059131
Source DB: PubMed Journal: Curr Mol Med ISSN： 1566-5240 Impact factor: 2.222