BACKGROUND: A high diagnostic accuracy of 64-slice CT coronary angiography (CTCA) has been reported in selected patients with stable angina pectoris, but only scant information is available in patients with non-ST elevation acute coronary syndrome (ACS). OBJECTIVES: To study the diagnostic performance of 64-slice CTCA in patients with non-ST elevation ACS. PATIENTS AND METHODS: 64-slice CTCA was performed in 104 patients (mean (SD) age 59 (9) years) with non-ST elevation ACS. Two independent, blinded observers assessed all coronary arteries for stenosis, using conventional quantitative angiography as a reference. Coronary lesions with >or=50% luminal narrowing were classified as significant. RESULTS: Conventional coronary angiography demonstrated the absence of significant disease in 15% (16/104) of patients, and the presence of single-vessel disease in 40% (42/104) and multivessel disease in 44% (46/104) of patients. Sensitivity for detecting significant coronary stenoses on a patient-by-patient analysis was 100% (88/88; 95% CI 95 to 100), specificity 75% (12/16; 95% CI 47 to 92), and positive and negative predictive values were 96% (88/92; 95% CI 89 to 99) and 100% (12/12; 95% CI 70 to 100), respectively. CONCLUSION: 64-slice CTCA has a high sensitivity to detect significant coronary stenoses, and is reliable to exclude the presence of significant coronary artery disease in patients who present with a non-ST elevation ACS.
BACKGROUND: A high diagnostic accuracy of 64-slice CT coronary angiography (CTCA) has been reported in selected patients with stable angina pectoris, but only scant information is available in patients with non-ST elevation acute coronary syndrome (ACS). OBJECTIVES: To study the diagnostic performance of 64-slice CTCA in patients with non-ST elevation ACS. PATIENTS AND METHODS: 64-slice CTCA was performed in 104 patients (mean (SD) age 59 (9) years) with non-ST elevation ACS. Two independent, blinded observers assessed all coronary arteries for stenosis, using conventional quantitative angiography as a reference. Coronary lesions with >or=50% luminal narrowing were classified as significant. RESULTS: Conventional coronary angiography demonstrated the absence of significant disease in 15% (16/104) of patients, and the presence of single-vessel disease in 40% (42/104) and multivessel disease in 44% (46/104) of patients. Sensitivity for detecting significant coronary stenoses on a patient-by-patient analysis was 100% (88/88; 95% CI 95 to 100), specificity 75% (12/16; 95% CI 47 to 92), and positive and negative predictive values were 96% (88/92; 95% CI 89 to 99) and 100% (12/12; 95% CI 70 to 100), respectively. CONCLUSION: 64-slice CTCA has a high sensitivity to detect significant coronary stenoses, and is reliable to exclude the presence of significant coronary artery disease in patients who present with a non-ST elevation ACS.
Authors: Michel E Bertrand; Maarten L Simoons; Keith A A Fox; Lars C Wallentin; Christian W Hamm; Eugene McFadden; Pim J De Feyter; Giuseppe Specchia; Witold Ruzyllo Journal: Eur Heart J Date: 2002-12 Impact factor: 29.983
Authors: W G Austen; J E Edwards; R L Frye; G G Gensini; V L Gott; L S Griffith; D C McGoon; M L Murphy; B B Roe Journal: Circulation Date: 1975-04 Impact factor: 29.690
Authors: Martijn S Dirksen; J Wouter Jukema; Jeroen J Bax; Hildo J Lamb; Eric Boersma; Joan C Tuinenburg; Jacob Geleijns; Ernst E van der Wall; Albert de Roos Journal: Am J Cardiol Date: 2005-02-15 Impact factor: 2.778
Authors: C P Cannon; W S Weintraub; L A Demopoulos; R Vicari; M J Frey; N Lakkis; F J Neumann; D H Robertson; P T DeLucca; P M DiBattiste; C M Gibson; E Braunwald Journal: N Engl J Med Date: 2001-06-21 Impact factor: 91.245
Authors: M T Roe; R A Harrington; D M Prosper; K S Pieper; D L Bhatt; A M Lincoff; M L Simoons; M Akkerhuis; E M Ohman; M M Kitt; A Vahanian; W Ruzyllo; K Karsch; R M Califf; E J Topol Journal: Circulation Date: 2000-09-05 Impact factor: 29.690
Authors: Ruchira Glaser; Howard C Herrmann; Sabina A Murphy; Laura A Demopoulos; Peter M DiBattiste; Christopher P Cannon; Eugene Braunwald Journal: JAMA Date: 2002-12-25 Impact factor: 56.272
Authors: D J Diver; J D Bier; P E Ferreira; B L Sharaf; C McCabe; B Thompson; B Chaitman; D O Williams; E Braunwald Journal: Am J Cardiol Date: 1994-09-15 Impact factor: 2.778
Authors: E di Cesare; I Carbone; A Carriero; M Centonze; F De Cobelli; R De Rosa; P Di Renzi; A Esposito; R Faletti; R Fattori; M Francone; A Giovagnoni; L La Grutta; G Ligabue; L Lovato; R Marano; M Midiri; L Natale; A Romagnoli; V Russo; F Sardanelli; F Cademartiri Journal: Radiol Med Date: 2012-04-01 Impact factor: 3.469
Authors: A Romagnoli; E Martuscelli; M Sperandio; C Arganini; B De Angelis; V Acampora; A Patrei; G Bazzocchi; F Romeo; G Simonetti Journal: Radiol Med Date: 2009-12-16 Impact factor: 3.469
Authors: Lars Husmann; Oliver Gaemperli; Tiziano Schepis; Hans Scheffel; Ines Valenta; Tobias Hoefflinghaus; Paul Stolzmann; Lotus Desbiolles; Bernhard A Herzog; Sebastian Leschka; Borut Marincek; Hatem Alkadhi; Philipp A Kaufmann Journal: Int J Cardiovasc Imaging Date: 2008-06-19 Impact factor: 2.357
Authors: Kelley R Branch; Janet Busey; Lee M Mitsumori; Jared Strote; James H Caldwell; Joshua H Busch; William P Shuman Journal: AJR Am J Roentgenol Date: 2013-05 Impact factor: 3.959