| Literature DB >> 17343309 |
Barry Bresnihan1, Danielle M Gerlag, Terence Rooney, Tom J M Smeets, Carla A Wijbrandts, David Boyle, Oliver Fitzgerald, Bruce W Kirkham, Iain B McInnes, Malcolm Smith, Ann-Kristin Ulfgren, Douglas J Veale, Paul P Tak.
Abstract
Successive studies from one academic center (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands) have consistently suggested that synovial tissue expression of sublining macrophages may be a biomarker of clinical response to therapeutic intervention in rheumatoid arthritis (RA) clinical trials. A proof-of-concept, randomized clinical trial was completed at a second academic center (St. Vincent's University Hospital, Dublin, Ireland), and the relationship between the change in disease activity and the change in sublining macrophages in distinct treatment cohorts was determined. The preliminary findings were not conclusive, but appeared to support a role for sublining CD68+ macrophages as a biomarker of clinical response to therapeutic intervention in cohorts of patients with RA.Entities:
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Year: 2007 PMID： 17343309
Source DB: PubMed Journal: J Rheumatol ISSN： 0315-162X Impact factor: 4.666