Literature DB >> 1734329

Decreased cerebral glucose utilization in myotonic dystrophy.

M Fiorelli1, D Duboc, B M Mazoyer, J Blin, B Eymard, M Fardeau, Y Samson.   

Abstract

To test the hypothesis that cerebral metabolism is altered in myotonic dystrophy (MyD), we investigated cerebral glucose kinetics and utilization in 11 adult patients with MyD and 14 healthy controls, using 18F-labeled 2-fluoro-2-deoxy-D-glucose (FDG) and dynamic positron emission tomography. Estimation of rate constants in MyD revealed a reduction of FDG delivery to the brain. Cortical glucose utilization rate was reduced by about 20% in MyD. These findings may be related to the presence of neurologic impairment in MyD and prompt further investigations on the metabolic and clinical features of brain dysfunction in this disease.

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Year:  1992        PMID： 1734329     DOI： 10.1212/wnl.42.1.91

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

1.  Proximal myopathy and diffuse white matter involvement in myotonic dystrophy type I.

Authors:  Kayihan Uluc; E Murat Arsava; Sevim Erdem; Ersin Tan
Journal:  J Neurol       Date:  2002-05       Impact factor: 4.849

2.  Metabolic control of resting hemispheric cerebral blood flow is oxidative, not glycolytic.

Authors:  William J Powers; Tom O Videen; Joanne Markham; Vonn Walter; Joel S Perlmutter
Journal:  J Cereb Blood Flow Metab       Date:  2011-02-09       Impact factor: 6.200

3.  Apathy and hypersomnia are common features of myotonic dystrophy.

Authors:  J S Rubinsztein; D C Rubinsztein; S Goodburn; A J Holland
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-04       Impact factor: 10.154

4.  Retrospective study on PET-SPECT imaging in a large cohort of myotonic dystrophy type 1 patients.

Authors:  Vincenzo Romeo; E Pegoraro; F Squarzanti; G Sorarù; C Ferrati; M Ermani; P Zucchetta; F Chierichetti; C Angelini
Journal:  Neurol Sci       Date:  2010-09-15       Impact factor: 3.307

5.  Brain metabolism after recurrent insulin induced hypoglycaemic episodes: a PET study.

Authors:  H Chabriat; C Sachon; M Levasseur; A Grimaldi; S Pappata; D Rougemont; M C Masure; A De Recondo; Y Samson
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-11       Impact factor: 10.154

6.  Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.

Authors:  Oscar Hernández-Hernández; Céline Guiraud-Dogan; Géraldine Sicot; Aline Huguet; Sabrina Luilier; Esther Steidl; Stefanie Saenger; Elodie Marciniak; Hélène Obriot; Caroline Chevarin; Annie Nicole; Lucile Revillod; Konstantinos Charizanis; Kuang-Yung Lee; Yasuhiro Suzuki; Takashi Kimura; Tohru Matsuura; Bulmaro Cisneros; Maurice S Swanson; Fabrice Trovero; Bruno Buisson; Jean-Charles Bizot; Michel Hamon; Sandrine Humez; Guillaume Bassez; Friedrich Metzger; Luc Buée; Arnold Munnich; Nicolas Sergeant; Geneviève Gourdon; Mário Gomes-Pereira
Journal:  Brain       Date:  2013-02-11       Impact factor: 13.501

7.  Intelligence quotient profile in myotonic dystrophy, intergenerational deficit, and correlation with CTG amplification.

Authors:  P Turnpenny; C Clark; K Kelly
Journal:  J Med Genet       Date:  1994-04       Impact factor: 6.318

8.  Brain involvement in myotonic dystrophies: neuroimaging and neuropsychological comparative study in DM1 and DM2.

Authors:  Vincenzo Romeo; E Pegoraro; C Ferrati; F Squarzanti; G Sorarù; A Palmieri; P Zucchetta; L Antunovic; E Bonifazi; G Novelli; C P Trevisan; M Ermani; R Manara; C Angelini
Journal:  J Neurol       Date:  2010-03-11       Impact factor: 4.849

9.  Neuropathology does not Correlate with Regional Differences in the Extent of Expansion of CTG Repeats in the Brain with Myotonic Dystrophy Type 1.

Authors:  Kyoko Itoh; Maki Mitani; Kunihiko Kawamoto; Naonobu Futamura; Itaru Funakawa; Kenji Jinnai; Shinji Fushiki
Journal:  Acta Histochem Cytochem       Date:  2010-12-18       Impact factor: 1.938

10.  Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle.

Authors:  Laura Valentina Renna; Francesca Bosè; Sara Iachettini; Barbara Fossati; Lorenzo Saraceno; Valentina Milani; Roberto Colombo; Giovanni Meola; Rosanna Cardani
Journal:  PLoS One       Date:  2017-09-15       Impact factor: 3.240
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