Literature DB >> 7964812

Brain metabolism after recurrent insulin induced hypoglycaemic episodes: a PET study.

H Chabriat1, C Sachon, M Levasseur, A Grimaldi, S Pappata, D Rougemont, M C Masure, A De Recondo, Y Samson.   

Abstract

Neuropsychological testing was carried out and the rate of oxygen metabolism in the brain was measured by PET in 15 highly selected patients with type 1 diabetes. The aim was to investigate the impact on the brain of hypoglycaemic comas resulting from insulin treatment. No significant difference was found between nine patients with a history of more than 10 hypoglycaemic comas and six others who denied any history of such events. These data suggest that intensified insulin treatment, although increasing the frequency of hypoglycaemic coma, may not always be harmful for the brain. This may be explained by the limited duration of hypoglycaemic coma induced by conventional insulin treatment.

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Year:  1994        PMID: 7964812      PMCID: PMC1073187          DOI: 10.1136/jnnp.57.11.1360

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN: 0022-3050            Impact factor:   10.154


  37 in total

1.  Oxidative metabolism of the cerebral cortex of the rat in severe insulin-induced hypoglycaemia.

Authors:  K Norberg; B K Siesiö
Journal:  J Neurochem       Date:  1976-02       Impact factor: 5.372

2.  CEREBRAL BLOOD FLOW AND METABOLISM IN THERAPEUTIC INSULIN COMA.

Authors:  P D PORTA; A T MAIOLO; V U NEGRI; E ROSSELLA
Journal:  Metabolism       Date:  1964-02       Impact factor: 8.694

3.  Neuroimaging in refractory partial seizures: comparison of PET, CT, and MRI.

Authors:  W H Theodore; R Dorwart; M Holmes; R J Porter; G DiChiro
Journal:  Neurology       Date:  1986-06       Impact factor: 9.910

4.  The 15O continuous-inhalation method: correction for intravascular signal using C15O.

Authors:  P Pantano; J C Baron; C Crouzel; P Collard; P Sirou; Y Samson
Journal:  Eur J Nucl Med       Date:  1985

5.  Brain damage in diabetes mellitus.

Authors:  R N Bale
Journal:  Br J Psychiatry       Date:  1973-03       Impact factor: 9.319

Review 6.  Biological differences between ischemia, hypoglycemia, and epilepsy.

Authors:  R N Auer; B K Siesjö
Journal:  Ann Neurol       Date:  1988-12       Impact factor: 10.422

7.  Effects of neonatal hypoglycaemia on the nervous system: a pathological study.

Authors:  J M Anderson; R D Milner; S J Strich
Journal:  J Neurol Neurosurg Psychiatry       Date:  1967-08       Impact factor: 10.154

8.  Computed tomographic imaging of the brain in after hypoglycemia coma.

Authors:  A Iwai; T Sakamoto; Y Kinoshita; J Yokota; T Yoshioka; T Sugimoto
Journal:  Neuroradiology       Date:  1987       Impact factor: 2.804

9.  Effects of thalamic stroke on energy metabolism of the cerebral cortex. A positron tomography study in man.

Authors:  J C Baron; R D'Antona; P Pantano; M Serdaru; Y Samson; M G Bousser
Journal:  Brain       Date:  1986-12       Impact factor: 13.501

10.  The temporal evolution of hypoglycemic brain damage. II. Light- and electron-microscopic findings in the hippocampal gyrus and subiculum of the rat.

Authors:  R N Auer; H Kalimo; Y Olsson; B K Siesjö
Journal:  Acta Neuropathol       Date:  1985       Impact factor: 17.088

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  5 in total

1.  Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function.

Authors:  Christopher T Kodl; Daniel T Franc; Jyothi P Rao; Fiona S Anderson; William Thomas; Bryon A Mueller; Kelvin O Lim; Elizabeth R Seaquist
Journal:  Diabetes       Date:  2008-08-11       Impact factor: 9.461

Review 2.  Cognitive dysfunction and diabetes mellitus.

Authors:  Christopher T Kodl; Elizabeth R Seaquist
Journal:  Endocr Rev       Date:  2008-04-24       Impact factor: 19.871

3.  Cognitive efficiency declines over time in adults with Type 1 diabetes: effects of micro- and macrovascular complications.

Authors:  C M Ryan; M O Geckle; T J Orchard
Journal:  Diabetologia       Date:  2003-06-18       Impact factor: 10.122

Review 4.  Brain changes in diabetes mellitus patients with gastrointestinal symptoms.

Authors:  Anne M Drewes; Eirik Søfteland; Georg Dimcevski; Adam D Farmer; Christina Brock; Jens B Frøkjær; Klaus Krogh; Asbjørn M Drewes
Journal:  World J Diabetes       Date:  2016-01-25

Review 5.  Hypoglycemia induced by insulin as a triggering factor of cognitive deficit in diabetic children.

Authors:  Vanessa Rodrigues Vilela; Any de Castro Ruiz Marques; Christiano Rodrigues Schamber; Roberto Barbosa Bazotte
Journal:  ScientificWorldJournal       Date:  2014-03-23
  5 in total

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