OBJECTIVE: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous blood product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. METHODS: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O) to 30 conventional systems (n=30, Dideco 903 Avant). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. RESULTS: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p=0.05), transfused volume (133.3+/-244.5 ml vs 325+/-483.1 ml, p<0.05), fresh frozen plasma (0 unit vs 3 units, p<0.001), postoperative bleeding (301.8+/-531.9 ml vs 785.5+/-1000.4 ml, p<0.05) and GME activity post-arterial filter (0.14 microl vs 5.32 microl, p<0.05). CONCLUSIONS: The adoption of mini-bypass significantly potentially reduces hemodilution, donor blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits.
RCT Entities:
OBJECTIVE: In an effort to minimize the effect of extracorporeal circulation (ECC), mini-bypass is gaining clinical acceptance in routine coronary artery bypass grafting (CABG). These small circuits target combine the clinical advantages of reduced prime, 100% bio-coating and suction blood separation. We demonstrate that the use of mini-bypass in routine CABG reduces homologous blood product use and postoperative bleeding. Our goal was to also demonstrate that these small systems are effective in gaseous microemboli (GME) management as compared to a conventional extracorporeal system. METHODS: Prospective, randomized study comparing 30 mini-bypass (Dideco ECC.O) to 30 conventional systems (n=30, Dideco 903 Avant). Study included CABG cases only, independent of preoperative coagulative status; clinic ethical committee approval and informed patient consent was obtained before initiating study. RESULTS: There were no statistical differences in terms of patient demographics. Statistically significant differences were seen in transfusion frequency (27% of the study group vs 43% in the control group, p=0.05), transfused volume (133.3+/-244.5 ml vs 325+/-483.1 ml, p<0.05), fresh frozen plasma (0 unit vs 3 units, p<0.001), postoperative bleeding (301.8+/-531.9 ml vs 785.5+/-1000.4 ml, p<0.05) and GME activity post-arterial filter (0.14 microl vs 5.32 microl, p<0.05). CONCLUSIONS: The adoption of mini-bypass significantly potentially reduces hemodilution, donor blood usage, postoperative bleeding and exposure to GME in routine CABG patients as compared to the use of conventional extracorporeal circulation circuits.
Authors: Aziz U Momin; Mansour T A Sharabiani; Emadin Kidher; Ali Najefi; John W Mulholland; Barnaby C Reeves; Gianni D Angelini; Jon R Anderson Journal: Interact Cardiovasc Thorac Surg Date: 2013-06-28
Authors: Koray Yuruk; Rick Bezemer; Mariska Euser; Dan M J Milstein; Hilde H R de Geus; Evert W Scholten; Bas A J M de Mol; Can Ince Journal: Interact Cardiovasc Thorac Surg Date: 2012-06-14
Authors: Johan Nilsson; Sara Scicluna; Gunnar Malmkvist; Leif Pierre; Lars Algotsson; Per Paulsson; Henrik Bjursten; Per Johnsson Journal: Interact Cardiovasc Thorac Surg Date: 2012-08-21
Authors: Anas Aboud; Hendrikje Mederos-Dahms; Kai Liebing; Armin Zittermann; Harald Schubert; Edward Murray; Andre Renner; Jan Gummert; Jochen Börgermann Journal: BMC Anesthesiol Date: 2015-05-29 Impact factor: 2.217