OBJECTIVES: To investigate the association between exposures to polycyclic aromatic hydrocarbons (PAH) that arises during asphalt paving, and risk of bladder cancer. METHODS: 7298 men included in the historical cohort were first employed between 1913 and 1999 in companies applying asphalt in Denmark, Norway, Finland and Israel. The minimal duration of employment for inclusion in the cohort was two seasons of work. Occupational histories were extracted from personnel files. A follow-up for cancer incidence was conducted through national cancer registries. The authors estimated exposures to benzo(a)pyrene as a marker for 4-6 ring PAH. Exposures were reconstructed by using information about changes in asphalt paving technology in each company over time, the modelled relation between production characteristics and exposure levels, and job histories. Relative risks and associated 95% confidence intervals were estimated using Poisson regression. RESULTS: 48 bladder cancers among asphalt paving workers were detected; of these, 39 cases were exposed at least 15 years before the diagnosis. Cumulative exposure to PAH was not associated with the incidence of bladder cancer. The association with average exposure became stronger when 15-year lag was considered, revealing a twofold increase in relative bladder cancer risk in the two higher exposure categories. There was an indication of exposure-response association with lagged averaged exposure. Risk estimates were adjusted for age, country, duration of employment and calendar period, did not show heterogeneity among countries and did not materially change when re-estimated after excluding non-primary cancers from follow-up. Previously conducted sensitivity analysis indicates that confounding by cigarette smoking is an unlikely explanation for the observed exposure-response trends. CONCLUSIONS: The authors were unable to control for all possible sources of confounding and bias. The results do not allow conclusion on the presence or absence of a causal link between exposures to PAH and risk of bladder cancer among asphalt workers.
OBJECTIVES: To investigate the association between exposures to polycyclic aromatic hydrocarbons (PAH) that arises during asphalt paving, and risk of bladder cancer. METHODS: 7298 men included in the historical cohort were first employed between 1913 and 1999 in companies applying asphalt in Denmark, Norway, Finland and Israel. The minimal duration of employment for inclusion in the cohort was two seasons of work. Occupational histories were extracted from personnel files. A follow-up for cancer incidence was conducted through national cancer registries. The authors estimated exposures to benzo(a)pyrene as a marker for 4-6 ring PAH. Exposures were reconstructed by using information about changes in asphalt paving technology in each company over time, the modelled relation between production characteristics and exposure levels, and job histories. Relative risks and associated 95% confidence intervals were estimated using Poisson regression. RESULTS: 48 bladder cancers among asphalt paving workers were detected; of these, 39 cases were exposed at least 15 years before the diagnosis. Cumulative exposure to PAH was not associated with the incidence of bladder cancer. The association with average exposure became stronger when 15-year lag was considered, revealing a twofold increase in relative bladder cancer risk in the two higher exposure categories. There was an indication of exposure-response association with lagged averaged exposure. Risk estimates were adjusted for age, country, duration of employment and calendar period, did not show heterogeneity among countries and did not materially change when re-estimated after excluding non-primary cancers from follow-up. Previously conducted sensitivity analysis indicates that confounding by cigarette smoking is an unlikely explanation for the observed exposure-response trends. CONCLUSIONS: The authors were unable to control for all possible sources of confounding and bias. The results do not allow conclusion on the presence or absence of a causal link between exposures to PAH and risk of bladder cancer among asphalt workers.
Authors: Igor Burstyn; Paolo Boffetta; Timo Kauppinen; Pirjo Heikkilä; Ole Svane; Timo Partanen; Isabelle Stücker; Rainer Frentzel-Beyme; Wolfgang Ahrens; Hiltrud Merzenich; Dick Heederik; Mariëtte Hooiveld; Sverre Langård; Britt G Randem; Bengt Järvholm; Ingvar Bergdahl; Judith Shaham; Joseph Ribak; Hans Kromhout Journal: Am J Ind Med Date: 2003-01 Impact factor: 2.214
Authors: Paolo Boffetta; Igor Burstyn; Timo Partanen; Hans Kromhout; Ole Svane; Sverre Langård; Bengt Järvholm; Rainer Frentzel-Beyme; Timo Kauppinen; Isabelle Stücker; Judith Shaham; Dick Heederik; Wolfgang Ahrens; Ingvar A Bergdahl; Sylvie Cenée; Gilles Ferro; Pirjo Heikkilä; Mariëtte Hooiveld; Christoffer Johansen; Britt G Randem; Walter Schill Journal: Am J Ind Med Date: 2003-01 Impact factor: 2.214
Authors: Jon R Sobus; Michael D McClean; Robert F Herrick; Suramya Waidyanatha; Leena A Nylander-French; Lawrence L Kupper; Stephen M Rappaport Journal: Ann Occup Hyg Date: 2009-07-14
Authors: Joanne Colt; Melissa Friesen; Patricia Stewart; Park Donguk; Alison Johnson; Molly Schwenn; Margaret Karagas; Karla Armenti; Richard Waddell; Castine Verrill; Mary Ward; Laura Beane Freeman; Lee Moore; Dalsu Baris; Debra Silverman Journal: Occup Environ Med Date: 2014-06 Impact factor: 4.402
Authors: Joanne S Colt; Melissa C Friesen; Patricia A Stewart; Park Donguk; Alison Johnson; Molly Schwenn; Margaret R Karagas; Karla Armenti; Richard Waddell; Castine Verrill; Mary H Ward; Laura E Beane Freeman; Lee E Moore; Stella Koutros; Dalsu Baris; Debra T Silverman Journal: Occup Environ Med Date: 2014-06-20 Impact factor: 4.402