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Literature DB >> 17328573

A library of noviosylated coumarin analogues.

Abstract

The DNA gyrase inhibitor, novobiocin, was recently shown to inhibit Hsp90 via a previously unrecognized C-terminal ATP-binding site. Previous structure-activity relationship studies identified key moieties that appear important for Hsp90 inhibitory activity. In an effort to provide a more efficacious lead compound, a parallel library of noviosylated coumarin analogues was prepared.

Entities: Chemical Gene

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Year: 2007 PMID： 17328573 DOI： 10.1021/jo062083t

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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Cited

12 in total

1. Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors.

Authors: Bhaskar Reddy Kusuma; Adam S Duerfeldt; Brian S J Blagg
Journal: Bioorg Med Chem Lett Date: 2011-10-01 Impact factor: 2.823

2. Targeting the heat shock protein 90 dimer with dimeric inhibitors.

Authors: Bhaskar Reddy Kusuma; Laura B Peterson; Huiping Zhao; George Vielhauer; Jeffrey Holzbeierlein; Brian S J Blagg
Journal: J Med Chem Date: 2011-08-23 Impact factor: 7.446

3. Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy.

Authors: Michael J Urban; Pan Pan; Kevin L Farmer; Huiping Zhao; Brian S J Blagg; Rick T Dobrowsky
Journal: Exp Neurol Date: 2012-03-20 Impact factor: 5.330

4. Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities.

Authors: Arlyn Tambo-ong; Sidharth Chopra; Bryan T Glaser; Karen Matsuyama; Tran Tran; Peter B Madrid
Journal: Bioorg Med Chem Lett Date: 2011-08-12 Impact factor: 2.823

5. Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity.

Authors: Huiping Zhao; Bhaskar Reddy Kusuma; Brian S J Blagg
Journal: ACS Med Chem Lett Date: 2010-07-13 Impact factor: 4.345

6. C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons.

Authors: Liang Zhang; Huiping Zhao; Brian S J Blagg; Rick T Dobrowsky
Journal: J Proteome Res Date: 2012-03-28 Impact factor: 4.466

A library of noviosylated coumarin analogues.

1. Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors.

2. Targeting the heat shock protein 90 dimer with dimeric inhibitors.

3. Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy.

4. Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities.

5. Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity.

6. C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons.

7. Design, synthesis, and biological evaluation of ring-constrained novobiocin analogues as hsp90 C-terminal inhibitors.

Review 8. Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

9. Novobiocin Analogues That Inhibit the MAPK Pathway.

Review 10. Natural product inhibitors of Hsp90: potential leads for drug discovery.